High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.

Irvine, Alan; McAleer, Maeve

doi:http://dx.doi.org/10.1038/ng.2642

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.

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emss-54941.pdf (157.34 KB)

Date

2013

Authors

Irvine, Alan

McAleer, Maeve

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openAccess

Citation

Ellinghaus D, Baurecht H, Esparza-Gordillo J, Rodr�guez E, Matanovic A, Marenholz I, H�bner N, Schaarschmidt H, Novak N, Michel S, Maintz L, Werfel T, Meyer-Hoffert U, Hotze M, Prokisch H, Heim K, Herder C, Hirota T, Tamari M, Kubo M, Takahashi A, Nakamura Y, Tsoi LC, Stuart P, Elder JT, Sun L, Zuo X, Yang S, Zhang X, Hoffmann P, N�then MM, F�lster-Holst R, Winkelmann J, Illig T, Boehm BO, Duerr RH, B�ning C, Brand S, Glas J, McAleer MA, Fahy CM, Kabesch M, Brown S, McLean WH, Irvine AD, Schreiber S, Lee YA, Franke A, Weidinger S, High-density genotyping study identifies four new susceptibility loci for atopic dermatitis., Nature genetics, 45, 7, 2013, 808-12

Abstract

Atopic dermatitis is a common inflammatory skin disease with a strong heritable component. Pathogenetic models consider keratinocyte differentiation defects and immune alterations as scaffolds, and recent data indicate a role for autoreactivity in at least a subgroup of patients. FLG (encoding filaggrin) has been identified as a major locus causing skin barrier deficiency. To better define risk variants and identify additional susceptibility loci, we densely genotyped 2,425 German individuals with atopic dermatitis (cases) and 5,449 controls using the Immunochip array followed by replication in 7,196 cases and 15,480 controls from Germany, Ireland, Japan and China. We identified four new susceptibility loci for atopic dermatitis and replicated previous associations. This brings the number of atopic dermatitis risk loci reported in individuals of European ancestry to 11. We estimate that these susceptibility loci together account for 14.4% of the heritability for atopic dermatitis.