Biological investigations of novel 1,8-naphthalimide compounds and the design and synthesis of pyridine based polyamides

Abstract

This thesis entitled "Biological Investigations of Novel 1,8-Naphthalimide Compounds and the Design and Synthesis of Pyridine Polyamides" is divided into six chapters. Chapter 1, the introduction focuses on the basic cellular mechanisms, such as growth and programmed cell death and their connection to cancer. Furthermore, the different means of inhibiting the growth of cancer cells is discussed, followed by examples of organic compounds that have been synthesised with that it mind. Special focus will be given to the genetic material, DNA and agents that have been designed to interact with it.