The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis

Abstract

The work presented in this thesis describes a comprehensive analysis of the YycFG two-com ponent system (TCS) in Bacillus subtilis. TCSs are widespread mechanisms used by bacteria to sense and respond to the prevailing environmental conditions. YycFG is the only essential TCS encoded in the B. subtilis genome, but the nature of its essentiality has not been established. In addition, its regulon is poorly defined.