Assessment of permeability enhancers for salmon calcitonin (sCT) across intestinal cell culture models

Abstract

A large number of proteins are now being used or tested as therapeutic agents, enzyme inhibitors or antibodies to combat human disease, therefore they are receiving increased recognition for both their high activity at low concentrations and their fundamental role in human body systems. The advent of recombinant DNA technology has led to an explosion in quantities and varieties of proteins, which are highly purified and are non-contaminated with blood-bourne diseases. As a result, protein pharmaceuticals are becoming extremely important tools that are enabling people to fight life-threatening diseases (Lloyd et al., 1998)