Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

Mills, Kingston; Corr, Sinead; Palsson Mcdermott, Eva; Mc Gettrick-Dillon, Anne

doi:http://dx.doi.org/10.1016/j.celrep.2019.08.072

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

Files

1-s2.0-S2211124719311271-main.pdf (3.32 MB)

Date

2019

Authors

Mills, Kingston

Corr, Sinead

Palsson Mcdermott, Eva

Mc Gettrick-Dillon, Anne

Access

openAccess

Citation

Hughes, M.M. and Hooftman, A. and Angiari, S. and Tummala, P. and Zaslona, Z. and Runtsch, M.C. and McGettrick, A.F. and Sutton, C.E. and Diskin, C. and Rooke, M. and Takahashi, S. and Sundararaj, S. and Casarotto, M.G. and Dahlstrom, J.E. and Palsson-McDermott, E.M. and Corr, S.C. and Mills, K.H.G. and Preston, R.J.S. and Neamati, N. and Xie, Y. and Baell, J.B. and Board, P.G. and O'Neill, L.A.J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 29, 1, 2019, 151-161.e5

Abstract

NLRP3 inflammasome activation contributes to chronic inflammationassociated with autoinflammatorydisease, yet understanding of NLRP3inflammasome regulation is incomplete.Hughes et al. show that thedeglutathionylating enzyme GSTO1-1promotes NLRP3 inflammasomeactivation through deglutathionylation ofNEK7. Furthermore, the GSTO1-1inhibitor C1-27 reduces NLRP3inflammasome activationin vitroandin vivo.