Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism

Kelly, Daniel; Mahon, Olwyn; McCarthy, Geraldine M.; Dunne, Aisling

doi:https://doi-org.elib.tcd.ie/10.1016/j.joca.2019.10.010

Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism

Files

Mahon_Manuscript_Final_OA&Cart. 2020.pdf (1.26 MB)

Date

2020

Authors

Kelly, Daniel

Mahon, Olwyn

McCarthy, Geraldine M.

Dunne, Aisling

Access

openAccess

Citation

Mahon, O.R., Kelly, D.J., McCarthy, G.M. & Dunne, A., Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism, Osteoarthritis and Cartilage, 28, 5, 2020, 603-612

Abstract

A number of studies have demonstrated that molecules called ‘alarmins’ or danger-associated molecular patterns (DAMPs), contribute to inflammatory processes in the OA joint. Metabolic reprogramming of immune cells, including macrophages, is emerging as a prominent player in determining immune cell phenotype and function. The aim of this study was to investigate if basic calcium phosphate (BCP) crystals which are OA-associated DAMPs, impact on macrophage phenotype and metabolism.