A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

Mc Manus, Ross; Feighery, Conleth; Kelleher, Dermot

doi:http://dx.doi.org/10.1038/ng2058

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

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Date

2007

Authors

Mc Manus, Ross

Feighery, Conleth

Kelleher, Dermot

Citation

van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR,, A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21., Nature Genetics, 39, 7, 2007, 827, 829

Abstract

We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 ? 10?7, empirical genome-wide significance P=0.045) was in the KIAA1109/Tenr/IL2/IL21 linkage disequilibrium block. Association was independently confirmed in two further collections (strongest at rs6822844, 24kB 5' of IL21, meta-analysis P=1.3 ? 10?14, OR 0.63), suggesting genetic variation in this region predisposes to celiac disease.