Characterisation of nanoparticle distribution, intergrity and toxicity in vivo and in vitro using advanced spectroscopic and microscopic approaches

Abstract

Much uncertainty surrounds the potential toxicity of new engineered nanomaterials to human health and the environment, either during manufacture, use or at the end of their life cycle. The current generalised methodologies used to assess the cytotoxicity of nanoparticle (NP) are inconclusive. A systematic approach, investigating NP distribution, integrity and cellular responses to NP exposure need to be applied. With such a broad range of NP available with different physical and chemical properties it is important to recognise that techniques tailored for investigating the interaction of particular NP with cells are required.