In vivo and in vitro mechanistic studies on targeting of lipophilic compounds to the intestinal lymphatics using lipid-based vehicles

Abstract

The aim of the experiments conducted in this thesis was to investigate the effect of a range of lipid-based vehicles on the intestinal lymphatic transport of triglycerides and of two lipophilic compounds- DDT and cyclosporine, in vivo in a mesenteric lymph ductcannulated model and in vitro in a Caco-2 cell culture model.