Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil

Abstract

Zanthoxylum piperitum DC. (ZP) is a traditional medicinal plant used mainly in countries from Asia such as Japan. This study aimed to investigate the antinociceptive effect of ZP essential oil (ZPEO).Themajor component present in the essential oil was betaphellandrene (29.39%). Its antinociceptive activity was tested through animalmodels (formalin-, capsaicin-, and glutamate-induced paw licking and hot plate).The anti-inflammatory effect was evaluated through the carrageenan-induced leukocyte migration into the subcutaneous air pouch (SAP), with measurement of cytokines. The results showed antinociceptive effect for ZPEO for the first phase of the formalin-induced licking, glutamate, and hot plate tests. However, ZPEO had no effect on reducing paw licking induced by capsaicin. Finally, ZPEO had no effect against inflammation induced by carrageenan.