Investigation of the oxidative folding pathway in Trypanosoma brucei

Abstract

In eukaryotic organisms the native structure of proteins destined to be secreted, such as immunoglobulins, or mounted surface proteins rely on the formation of disulphide bridges between cysteine residues for structural integrity. These bonds are thought to be formed in the endoplasmic reticulum via a pathway commonly referred to as the oxidative folding pathway.