• Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation

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    2011

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    Robert B. P. Elmes, Marialuisa Erby, Suzanne M. Cloonan, Susan J. Quinn, D. Clive Williams and Thorfinnur Gunnlaugsson, Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation, Chemical Communications, 47, 2011, 686 - 688

    Abstract

    The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.

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    PUBLISHED

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    http://hdl.handle.net/2262/64079

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    Chemistry (Scholarly Publications)
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    Keywords

    quaternarized pdppz derivative 1, dppz derivative, cellular death, apoptosis

    Sponsor: Science Foundation Ireland (SFI)
    Grant Number: SFI RFP 2009

    Sponsor: Higher Education Authority (HEA)

    Sponsor: Irish Research Council for Science and Engineering Technology (IRCSET)

    Author's Homepage: http://people.tcd.ie/dwillims

    Author: Williams, David

    Author: Gunnlaugsson, Thorfinnur

    Author: Cloonan, Suzanne

    Type of material: Journal Article