A role for IL-1B in oxidative stress-mediated neuronal impairment

Abstract

The aims of this study were to; (1) investigate age-related changes in the antioxidant defence system in the rat cortex and hippocampus; (2) investigate the role of IL-1β in influencing oxidative stress in brain tissue of aged and stressed rats; (3) to establish the efficacy of dietary supplementation with antioxidants in reversing the functional impairment seen in the hippocampus of stressed and IL-1β-treated rats.