Selective gene fishing in complex genomic environments using micro-cantilevers : applications in RNAi therapy

Abstract

Genes and their role in disease origins and proliferation have been of great interest for molecular medicine. Their functions and roles have been recently shown to be moderated by RNA interference (RNAi), a natural phenomenon occurring in living cells where short sequences of oligonucleotides (on an average ~22 base pairs) are known to control gene expression via gene silencing.