Towards a comprehensive system for the recognition of double helical DNA : Components for base pair recognition in the major groove

Abstract

This thesis describes the attempted synthesis of sequence selective double-stranded DNA-binding ligands. It had been intended to provide a comprehensive DNA recognition system via two different tricyclic heterocyclic motifs. The (5,5,5) pyrrolo [2', 3' : 4, 5] thieno [3, 2-d] thiazole system 1.52 was proposed to recognise A-T/T-A base pairs, and the functionalised (6,4,6)-tricyclic heterocyclic system 1.56 would recognise G-C/C-G base pairs.