The folate catabolic process, its implications for folate requirement in humans and its antibacterial drug function

Abstract

The one-carbon cycle, of which folate is the predominant constituent, is a major carrier of one-carbon units for biochemical synthesis, and is thought to be the sole mechanism of methyl-group transfer. It is involved both in purine and pyrimidine biosynthesis, in the regulation of transcription and epigenics, and in the synthesis of important biological compounds.