Development of SFV-based plasmid electroporation for use in tumour treatment and vaccine delivery

Abstract

Electroporation is the delivery of short and intense electric pulses into living cells (either in tissue or suspension), which results in a transient and reversible increase in permeability of the cell transmembrane. This study is designed to develop electroporation for use as a method of Semliki Forest virus (SFV) - based plasmid delivery for both tumour treatment and vaccine delivery.