Towards a comprehensive system for the recognition of double helical DNA : components for T and A

Abstract

This thesis gives an account of the attempted synthesis of sequence selective double stranded DNA ligands. Two distinctive ligands types were envisaged, a pyrrolo[2', 3': 4, 5] thieno [2, 3-d]imidazole system (1.40 and 1.41) for the binding to the T-A/A-T base pairs, and an N-carbamoyl squaramide system (1.44) for binding the G-C/C-G base pairs.