The effects of group II mGluR agonists on short-term depression and neutral coding in the rat dentate gyrus in vitro

Abstract

Short-term depression is an activity-dependent reduction in synaptic efficacy which has been observed at a wide variety of synapses in the CNS, and is often attributed to a depletion of the available store of neurotransmitter. At the medial and lateral perforant path-granule cell synapses, short trains of stimuli at a range of frequencies between 0.5 Hz and 200 Hz resulted in a reversible depression of the evoked EPSP amplitude.