• Regulatory T cell induction and function

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    Date

    2009

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    Trinity College (Dublin, Ireland). School of Biochemistry and Immunology

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    Kevin Walsh, 'Regulatory T cell induction and function', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009, pp 300

    Abstract

    The main objective of this study was to examine novel methods of inducing regulatory T (Treg) cells by modulating dendritic cell (DC) activation. It has previously been reported that TLR agonists stimulate IL-12 production from DC and thereby induce Th1 cells. However, recent studies have suggested that TLR agonists may simultaneously induce IL-10 producing Treg (Tr1) cells. In the present study, this property was explored and exploited in order to develop methods of selectively inducing Tr1 cells, in the development of potential therapies for auto-immune diseases mediated by Th1 and IL-17 producing T (Th17) cells.

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    http://hdl.handle.net/2262/78647

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    Biochemistry (Theses and Dissertations)
    Trinity College Dublin Theses & Dissertations

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    Keywords

    Biochemistry, Ph.D., Ph.D. Trinity College Dublin

    Author: Walsh, Kevin

    Qualification name: Doctor of Philosophy (Ph.D.)
    Publisher: Trinity College (Dublin, Ireland). School of Biochemistry and Immunology
    Type of material: thesis