• A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

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    2019

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    Doherty W., Durr E.-M., Baddock H.T., Lee S.Y., McHugh P.J., Brown T., Senge M.O., Scanlan E.M., McGouran J.F., A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A, Organic and Biomolecular Chemistry, 17, 35, 2019, 8094 - 8105

    Abstract

    Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors.

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    https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB01133A#!divAbstract
     http://hdl.handle.net/2262/91282

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    Chemistry (Scholarly Publications)
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    Keywords

    DNA repair, Nuclease SNM1A, Cancer treatment
    Author's Homepage: http://people.tcd.ie/jmcgoura

    Author: Mcgouran, Joanna

    Author: Senge, Mathias

    Author: Scanlan, Eoin

    Type of material: Journal Article