• The role of MyD88 in embryonal carcinoma stem cells

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    2015

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    Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy

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    Gomaa M. A. Sulaiman, 'The role of MyD88 in embryonal carcinoma stem cells', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015, pp 177

    Abstract

    Tumour-initiating cells are known to share some properties with stem cells. These so called 'Cancer Stem Cells' (CSCs) are highly tumourigenic in the undifferentiated state, a property that is lost upon CSC differentiation. For many years, our group has studied CSC differentiation in a nullipotent embryonal carcinoma CSC cell line (2102Ep), which can resist differentiation to produce highly-aggressive tumours. Previous work in the lab highlighted a potential role for Toll-Like Receptor (TLR) Signaling mediator protein Myeloid Differentiation Response Gene 88 (MyD88) in the mechanism through which 2102Ep cells resist differentiation.

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    http://hdl.handle.net/2262/90619

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    Histopathology & Morbid Anatomy (Theses and Dissertations)
    Trinity College Dublin Theses & Dissertations

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    Histopathology & Morbid Anatomy, Ph.D., Ph.D. Trinity College Dublin.

    Author: Sulaiman, Gomaa M. A.

    Qualification name: Doctor of Philosophy (Ph.D.)
    Publisher: Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy
    Type of material: thesis