Unconventional T cells - New players in antifungal immunity
Citation:
Dunne MR, Wagener J, Loeffler J, Doherty DG, Rogers TR, Unconventional T cells - New players in antifungal immunity., Clinical Immunology, 2021 Jun;227:108734Download Item:
Abstract:
Life-threatening invasive fungal diseases (IFD) are increasing in incidence, especially in immunocompromised patients and successful resolution of IFD requires a variety of different immune cells. With the limited repertoire of available antifungal drugs there is a need for more effective therapeutic strategies. This review interrogates the evidence on the human immune response to the main pathogens driving IFD, with a focus on the role of unconventional lymphocytes e.g. natural killer (NK) cells, gamma/delta (γδ) T cells, mucosal associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells and innate lymphoid cells (ILC). Recent discoveries and new insights into the roles of these novel lymphocyte groups in antifungal immunity will be discussed, and we will explore how an improved understanding of antifungal action by lymphocytes can inform efforts to improve antifungal treatment options.
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http://people.tcd.ie/dohertdeDescription:
PUBLISHED
Author: Doherty, Derek
Type of material:
Journal ArticleCollections
Series/Report no:
Clinical Immunology;227;
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Full text availableKeywords:
Unconventional lymphocytes, Natural killer cells, Mucosa associated invariant T cells, Invasive fungal disease, Invariant natural killer T cells, Innate lymphoid cells, Immunotherapy, Gamma delta T cellsSubject (TCD):
Immunology, Inflammation & InfectionDOI:
10.1016/j.clim.2021.108734Metadata
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