A murine model for celebral toxocariasis : characterisation of susceptibility, behaviour and immune response
Citation:
Clare M. Hamilton, 'A murine model for celebral toxocariasis : characterisation of susceptibility, behaviour and immune response', [thesis], Trinity College (Dublin, Ireland). Department of Zoology, 2006, pp 237Download Item:
Hamilton TCD THESIS 7840 A murine.pdf (PDF) 144.5Mb
Abstract:
Toxocara canis, the parasitic roundworm of dogs, can infect a number of paratenic
hosts, such as mice and humans, due to the widespread dissemination of its ova in the
environment (Glickman and Schantz, 1981). In the murine host, larvae have been
shown to exhibit a predilection for the central nervous system, resulting in an
increasing number of parasites in the brain as infection progresses (Sprent, 1955;
Dunsmore et al, 1983; Skerret and Holland, 1997). In previous research, cerebral larval
burdens have been correlated with various aherations in murine behaviour (Burright et
al, 1982; Dolinsky et al, 1985; Cox and Holland, 1998; 2001a,b), and burdens have
been shown to vary between individual outbred mice receiving the same inocula (Cox
and Holland, 2001a; Skerret and Holland, 1997), suggesting a role of immunity and
host genetics in the establishment of cerebral infection. Though T. canis has been
shown to induce a Th2 systemic immune response (Del Prete et al, 1991; Buijs et al,
1994; Cuellar et al, 2001), the cerebral immune response has received no attention.
The thesis presented here represents an investigation of the differential brain
involvement of T. canis in mice of contrasting genetic background - with
characterisation of the humoral and cerebral immune response in two inbred strains of
mice, and the simultaneous assessment of cerebral larval accumulation and behavioural
alterations.
Author: Hamilton, Clare M.
Advisor:
Holland, CeliaQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). Department of ZoologyNote:
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Zoology, Ph.D., Ph.D. Trinity College DublinLicences: