Browsing Mechanical, Manufacturing & Biomedical Eng by Author "VINARDELL, TATIANA"
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Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation.
BUCKLEY, CONOR; VINARDELL, TATIANA; KELLY, DANIEL (2014)Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) can be leveraged to generate bone in vivo by executing an endochondral program, leading to increased interest in the use of such hypertrophic grafts ... -
Chondrogenesis and integration of mesenchymal stem cells within an in vitro cartilage defect repair model
BUCKLEY, CONOR; KELLY, DANIEL; VINARDELL, TATIANA (2009)Integration of repair tissue is a key indicator of the long-term success of cell-based therapies for cartilage repair. The objective of this study was to compare the in vitro chondrogenic differentiation and integration ... -
Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad
KELLY, DANIEL; BUCKLEY, CONOR; VINARDELL, TATIANA (2011)The objective of this study was to determine the functional properties of cartilaginous tissues generated by porcine MSCs isolated from different tissue sources, and to compare these properties to those derived from ... -
Coupling freshly isolated CD44+ infrapatellar fat pad derived stromal cells with a tgf-β3 eluting cartilage ecm-derived scaffold as a single stage strategy for promoting chondrogenesis.
KELLY, DANIEL; VINARDELL, TATIANA; BUCKLEY, CONOR (2015) -
Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells.
VINARDELL, TATIANA; KELLY, DANIEL; CAMPBELL, VERONICA ANN; BUCKLEY, CONOR TIMOTHY (2008)The objective of this study was to investigate the influence of dynamic compressive loading on chondrogenesis of mesenchymal stem cells (MSCs) in the presence of TGF-?3. Isolated porcine MSCs were suspended in 2% agarose ... -
Engineering cartilage or endochondral bone: A comparison of different naturally derived hydrogels.
VINARDELL, TATIANA; KELLY, DANIEL (2015)Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) have been shown to generate bone in vivo by executing an endochondral programme. This may hinder the use of MSCs for articular cartilage regeneration, ... -
Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing
KELLY, DANIEL; VINARDELL, TATIANA; CUNNIFFE, GR?INNE; O'BRIEN, FERGAL (2015)Clinical translation of tissue engineered therapeutics is hampered by the significant logistical and regulatory challenges associated with such products, prompting increased interest in the use of decellularized extracellular ... -
Tissue engineering scaled-up, anatomically shaped osteochondral constructs for joint resurfacing
KELLY, DANIEL; BUCKLEY, CONOR; VINARDELL, TATIANA (2015)Arthroplasty is currently the only surgical procedure available to restore joint function following articular cartilage and bone degeneration associated with diseases such as osteoarthritis (OA). A potential alternative ...