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Now showing items 11-17 of 17
Functional analyses of a novel leucine-rich repeat-containing protein, Elfn1, in the mouse
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)
The functional brain is critically dependent on a highly specific and perfectly timed
gene-expression programme that underlies neuronal connectivity. Each step of
this process, which includes cell migration, axon guidance, ...
Investigating regulation of gene transcription by the Tup1-Ssn6 co-repressor complex in Saccharomyces cerevisiae
(Trinity College (Dublin, Ireland). Department of Microbiology, 2015)
Transcriptional repression is an important part of gene regulation. In the budding
yeast Saccharomyces cerevisiae the Tup1-Ssn6 corepressof complex is recruited to
gene promoters to repress transcription in response to ...
Genetic mechanisms establishing thalamocortical connectivity : novel genes and a role for Semaphorin6B
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)
One of the main functions of the brain is to process information from the
environment. All input to the neocortex passes through the thalamus in order to be
handled. Therefore, proper connectivity between the thalamus and ...
Identification and characterisation of a novel Polycomb Repressive Complex 2 associated protein that is an alternatively spliced product of the LCOR gene locus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2015)
Polycombs are evolutionary conserved epigenetic regulators crucial for
specification of cell types during development. They assemble in multiprotein
complexes to modify amino terminal tails of histone H3 at lysine 27 to ...
Dissecting the functional link between transcription factor codes and axon guidance genes in Drosophila motor neurons
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)
As axons navigate through the extracellular environment they are exposed to
different guidance cues that will steer them when sensed by receptors and cell
adhesion molecules [CAMS) present on their membranes. The intricate ...
Olfactory-avoidance habituation in Drosophila melanogaster
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)
Habituation is a form of sensory filtering in response to prolonged or repeated stimuli in the environment [Harris, 1943; Thompson and Spencer, 1966; Christoffersen, 1997; Rankin et al., 2009], It provides biological ...
Investigation of the molecular mechanisms of functional innovation
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)
The robustness to perturbations and evolvability of genomes are two major principles
that govern the emergence of genetic diversity across all forms of life. Functional
innovations that occur through the genetic diversity ...