Browsing Trinity College Dublin Theses & Dissertations by Sponsor "Wellcome Trust"
Now showing items 1-11 of 11
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An analysis platform and tools to understand the dynamics of neuronal encoding in rodents
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2019)The principal goal of the proposed project is to develop a data analysis framework that incorporates analytical methods for the study of cognitive map represented by neurons in vivo recorded from chronically implanted ... -
Citrate, oxaloacetate and 2-hydroxyglutarate in the control of inflammatory macrophage activation
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Immunometabolism is the study of changes that occur in the metabolic pathways of an immune cell during its activation. For macrophages, the remodelling of their metabolism following activation supports the adoption of ... -
Design and development of a hydrogel formulation with nanoparticles for the treatment of glioblastoma multiforme
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Glioblastoma multiforme (GBM) is the most aggressive form of brain tumours. GBM treatment is challenging because tumours are highly invasive and it is difficult to achieve effective therapeutic doses of drugs into the ... -
Early Immune Responses to Emerging and Enduring Respiratory Pathogens
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)For most of recent history, Tuberculosis (TB) has been the leading cause of death by an infective agent worldwide. Tuberculosis is caused by Mycobacterium tuberculosis (Mtb), which infects human lungs following respiratory ... -
Exploring the molecular mechanisms of Rett syndrome
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Rett Syndrome (RTT) is a severe neurological disorder that onsets between 6 to 18 months of age, after a period of apparently normal development. RTT affects approximately 1 in every 10000 to 15000 live births and is ... -
The Immunomodulatory Metabolite Itaconate Regulates NLRP3 Inflammasome Activation and Type I Interferon Signalling
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)The NLRP3 inflammasome is a multi-protein complex which activates caspase-1 for the cleavage and release of mature IL-1β and IL-18. Caspase-1 also cleaves gasdermin D, driving a process called pyroptosis. Results from ... -
Interactions Between Systemic Inflammation, Frailty And Neuroinflammation In Ageing And Neurodegeneration
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Compelling evidence continues to define the pivotal role which inflammation plays in the progression of neurodegenerative diseases and ageing. It has emerged that inflammation outside the brain significantly contributes ... -
Investigating the role of cell wall-anchored proteins during Staphylococcus aureus skin infection and as vaccine antigens
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Staphylococcus aureus has become increasingly resistant to antibiotics and community acquired methicillin resistant S. aureus (CA-MRSA) skin and soft tissue infections (SSTIs) are occurring with increasing frequency in ... -
Mesoporous Silica Nanocarriers for triggered drug delivery in the treatment of cancer
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Cancer is the second leading cause of death globally, accounting for 10 million deaths in 2020. Cancer chemotherapy is currently limited by a high systemic toxicity that occurs as a result of high systemic dosing and the ... -
PKM2 regulation of metabolism but not transcription is important for natural killer cell responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating signal transduction and cellular metabolism is essential for effective NK cells responses. The PKM2 isoform of the ... -
The role of IL-1 and Type I IFN in CNS function
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Cytokines including interleukins (ILs) and interferons (IFNs) are induced in response to tissue injury, infection or inflammation. Peripheral cytokines signal to the healthy Central Nervous System (CNS) to produce ...