Browsing Trinity College Dublin Theses & Dissertations by Sponsor "Marie Curie"
Now showing items 1-18 of 18
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Analysis of Offshore Wind Turbines : Probabilistic assessment of operational design
(Trinity College Dublin. School of Engineering. Disc of Civil Structural & Environmental Eng, 2019)The demand for renewable energy is unquestionable. Global climate trends have been fomenting the urge for renewable, low carbon-footprint technologies. Wind energy is one of the most prominent alternatives to conventional ... -
Antimicrobial formulation and functionalization of photosensitizers for antimicrobial photodynamic therapy (aPDT)
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)To provide a long-lasting solution to infections affecting the current world scenario, antimicrobial photodynamic therapy (aPDT) offers a non-invasive means to destroy pathogenic microbes via formation of reactive oxygen ... -
Elemental and isotope fingerprint of metal deficiency in soils
(Trinity College Dublin. School of Natural Sciences. Discipline of Geology, 2018)Metal deficiency in soils is a frequently observed phenomenon in (sub)-tropical regions, and both natural and anthropogenic processes contribute to the depletion of soil reservoirs. Advanced chemical weathering, in old ... -
Evidence of a role for Interleukin-6 in anoikis resistance and bioenergetic programming in oral squamous cell carcinoma
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Oral squamous cell carcinoma (OSCC) is the sixth most common type of cancer in the world and accounts for more than 90% of oral malignancies. Oral squamous cell carcinomas are usually preceded by oral premalignant ... -
Higher Spin Theories in Twistor Space
(Trinity College Dublin. School of Mathematics. Discipline of Pure & Applied Mathematics, 2018)In this thesis we formulate an action principle for conformal higher spin theory on twistor space. For this theory, and for a unitary sub-sector that we identify, we construct an MHV amplitude expansion by considering ... -
Identification and Measurement of Variables Affecting Component Lifetime: A Case Study of Polymer Degradation in the Biopharmaceutical Industry
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)Modern maintenance methods are dependent upon understanding and monitoring component degradation; however, many industrial situations exist where monitoring is impossible, and component degradation mechanisms are not well ... -
Identification of novel innate immune mechanisms regulating oesophageal adenocarcinoma (OAC) progression and bacterial infection
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Inflammation is an essential immune system response to pathogens, damaged cells and stress stimuli and has an essential role in tissue repair and regeneration. The inflammatory response is the coordinated activation of ... -
In-depth Analytical Platforms Facilitating Serum Glycome, Proteome and Glycoproteome Investigation for Biomarker Discovery
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Human serum is a great source of potential protein disease biomarkers because of how blood interacts with all parts of the body, allowing it to contain proteins secreted from specific tissues of interest, and due the ... -
Investigating Polyvictimisation in Child Abuse Cases: A multi-method study within a Danish Child Protection Context
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2020)Background: Child maltreatment is a universal problem with serious impacts on mental and physical health. The extant literature suggests that different forms of childhood harms tend to co-occur and that exposure to multiple ... -
Magnetic field effects on water and aqueous solutions
(Trinity College Dublin. School of Physics. Discipline of Physics, 2022)Claims of magnetic field effects on water and their potential use in a microfluidic channel are explored. The pendant drop method is used to measure the surface tension, which is calculated from the shape of the drop. The ... -
Molecular investigation of mitophagy in neuronal cell models
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Autophagy functions as a cellular recycling and quality control pathway and is likely responsible for maintenance of viable mitochondria by mitophagy, even though exact mechanisms remain unclear. Mitophagy is characterised ... -
New solid forms of itraconazole and their pharmaceutical applications
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Itraconazole (ITR) is an active pharmaceutical ingredient (API) with a broad-spectrum antifungal activity. This API has a very low solubility, which can hinder its bioavailability after oral administration. In this work, ... -
Prefrontal Contributions to Attention in Ageing and Stroke: Implications for Cognitive Reserve
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2017)Abstract M?adhbh B. Brosnan Prefrontal contributions to attention in ageing and stroke: implications for cognitive reserve. Global life expectancy is increasing dramatically with a corresponding rise in the prevalence ... -
Targeting the NMDA receptor/NO signalling pathway following L-α aminoadipic acid-induced astrocytic impairment and associated changes in the structural plasticity of neurons
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)This investigation firstly aims to characterise the impact of astrocytic dysfunction on neurons in vitro, specifically the effects of L-α amino adipic acid (L-AAA)-induced astrocytic dysfunction on neurite outgrowth and ... -
Towards the Successful Implementation of Low-Intensity Psychological Interventions: Implementing Problem Management Plus for Venezuelan Migrants and Refugees
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2020)Despite available evidence on effective psychological interventions, in low and middle income countries most forcibly displaced persons with mental health problems do not receive any type of mental health care. The last ... -
Tumour microenvironment, extracellular vesicles and their effect on prostate cancer progression and docetaxel resistance
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Prostate cancer is the fourth most common cancer in Europe and the third leading cause of death in males. The standard of care as initial treatment for prostate cancer is, typically, androgen-deprivation therapy. Although ... -
User Acceptance of Health and Mental Health Care Technologies
(Trinity College Dublin. School of Computer Science & Statistics. Discipline of Computer Science, 2022)Health and wellbeing is a rapidly growing area within Human-Computer Interaction (HCI). In recent years, many have developed systems, theoretical stances, and methodologies that aim at positioning information and communication ... -
Validation of numerical methods in cold spray by direct nozzle-internal measurements of non-dilute particle motion
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)This work presents the research conducted during the development of a new optical particle velocity measurement in the field of Cold Spray. Cold Spray is a process for surface coating formation and additive manufacturing, ...