Browsing School of Pharmacy and Pharmaceutical Sciences by Title
Now showing items 546-565 of 640
-
Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders
(2017)The kynurenine pathway (KP), which is activated in times of stress and infection has been implicated in the pathophysiology of neurodegenerative and psychiatric disorders. Activation of this tryptophan metabolising pathway ... -
Studies in the design and synthesis of novel selective serotonin reuptake inhibitors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)The serotonin transporter (SERT) has been the target of several modern day antidepressants with the focus on achieving selectivity over other monoamine transporters, thereby minimising the side effects observed in the older ... -
Studies in the synthesis and impurity profiling of Methylenedioxy and Alkylthioamphetamines
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)3,4-Methylenedioxymethamphetamme (MDMA, Ecstasy) and other, so-called, designer amphetamines, have become popular drugs of abuse over the past number of years. Detailed knowledge of the synthetic methods employed by ... -
Studies in the synthesis and in vitro hydrolysis of novel aspirin prodrugs
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)Prolonged aspirin use has been associated with an increased risk of gastrointestinal bleeding, leading in some instances to haemorrhage and death. This thesis describes the design of aspirin prodrugs, from which aspirin ... -
Studies into the in vitro metabolism and antiplatelet effects of novel aspirin ester prodrugs
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)Aspirin is the most commonly used antiplatelet agent in the world, and is invaluable in prevention o f myocardial infarction, thrombosis and stroke. However prolonged use has been associated with gastrointestinal side-effects ... -
Studies on the design, synthesis and stability of novel anti-allergy agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The purpose of this project was to design and synthesise novel classes of anti-allergy compounds using 1-tetralone as the principal building block. This thesis is introduced with an overview of the prominent role played ... -
Studies on Tinospora cordifolia monosugars and correlation analysis of uronic acids by spectrophotometry and GLC
(2014)Cold water-soluble (CWSP) and hot water soluble polysaccharides (HWSP) from Tinospora cordifolia stems were isolated and purified in 2.99% and 1.99% yield respectively. Complete hydrolysis followed by paper chromatography ... -
A study of glial associated changes in the complexity of primary cortical neurons
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Neuroinflammation and disruptions in the integrity of neuronal circuitry are hallmarks of a range of CNS disorders. There is extensive evidence linking pro-inflammatory signalling and glial dysfunction with neuronal atrophy ... -
A study of pharmacy practice. Non-prescribed medicines sales and counselling 3
(Swedish Pharmaceutical Press, 1991) -
Study on the antinociceptive activity and mechanism of action of isolated saponins from siolmatra brasiliensis (Cogn.) Baill
(2019)Infusions of roots of Siolmatra brasiliensis (Cogn.) Baill, (“taiuiá”, “cipó-tauá”) are used for toothache pain and ulcers. We aimed to study the antinociceptive effects and identify the possible mechanism of action of ... -
Submerged Eutectic-Assisted, Solvent-Free Mechanochemical Formation of a Propranolol Salt and Its Other Multicomponent Solids
(2021)Salt preparation via a solid-state reaction offers a solution to challenges posed by current pharmaceutical research, which include combining development of novel forms of active pharmaceutical ingredients with greener, ... -
Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung
(2014)Targeted aerosol delivery to specific regions of the lung may improve therapeutic efficiency and minimise unwanted side effects. Targeted delivery could potentially be achieved with porous microparticles loaded with ... -
Synthesis and antiproliferative action of a novel series of maprotiline analogues
(2014)The synthesis of a diverse library of compounds structurally related to maprotiline, a norepinephrine reuptake transporter (NET) selective antidepressant which has recently been identified as a novel in vitro antiproliferative ...