Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
Citation:
Bellenguez C, Bevan S, Gschwendtner A, Spencer CC, Burgess AI, Pirinen M, Jackson CA, Traylor M, Strange A, Su Z, Band G, Syme PD, Malik R, Pera J, Norrving B, Lemmens R, Freeman C, Schanz R, James T, Poole D, Murphy L, Segal H, Cortellini L, Cheng YC, Woo D, Nalls MA, Muller-Myhsok B, Meisinger C, Seedorf U, Ross-Adams H, Boonen S, Wloch-Kopec D, Valant V, Slark J, Furie K, Delavaran H, Langford C, Deloukas P, Edkins S, Hunt S, Gray E, Dronov S, Peltonen L, Gretarsdottir S, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Boncoraglio GB, Parati EA, Attia J, Holliday E, Levi C, Franzosi MG, Goel A, Helgadottir A, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski J, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Worrall BB, Kittner SJ, Mitchell BD, Kissela B, Meschia JF, Thijs V, Lindgren A, Macleod MJ, Slowik A, Walters M, Rosand J, Sharma P, Farrall M, Sudlow CL, Rothwell PM, Dichgans M, Donnelly P, Markus HS, Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke., Nature genetics, 44, 3, 2012, 328-33Download Item:
ukmss-40301.pdf (Published (publisher's copy) - Peer Reviewed) 1.761Mb
Abstract:
Genetic factors have been implicated in stroke risk but few replicated associations have been
reported. We conducted a genome-wide association study (GWAS) in ischemic stroke and its
subtypes in 3,548 cases and 5,972 controls, all of European ancestry. Replication of potential
signals was performed in 5,859 cases and 6,281 controls. We replicated reported associations
between variants close to
PITX2
and
ZFHX3
with cardioembolic stroke, and a 9p21 locus with
large vessel stroke. We identified a novel association for a SNP within the histone deacetylase 9
(
HDAC9
) gene on chromosome 7p21.1 which was associated with large vessel stroke including
additional replication in a further 735 cases and 28583 controls (rs11984041, combined P =
1.87?10
?11
, OR=1.42 (95% CI) 1.28-1.57). All four loci exhibit evidence for heterogeneity of
effect across the stroke subtypes, with some, and possibly all, affecting risk for only one subtype.
This suggests differing genetic architectures for different stroke subtypes
Sponsor
Grant Number
Wellcome Trust
WT084724MA
Medical Research Council (MRC)
G0000934
Wellcome Trust
085475/Z/08/Z
Wellcome Trust
085475/B/08/Z
Wellcome Trust
068545/Z/02
Author's Homepage:
http://people.tcd.ie/acorvinDescription:
PUBLISHED
Author: CORVIN, AIDEN PETER
Type of material:
Journal ArticleCollections:
Series/Report no:
Nature genetics44
3
Availability:
Full text availableKeywords:
Cerebrovascular disease (stroke)Licences: