Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.
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2009Citation:
O'Donovan MC, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Giegling I, Hartmann AM, Moller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Adolfsson R, Osby U, Terenius L, Jonsson EG, Cichon S, Nothen MM, Gill M, Corvin AP, Rujescu D, Gejman PV, Kirov G, Craddock N, Williams NM, Owen MJ., Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2., Molecular Psychiatry, 14, 1, 2009, 30 - 36Download Item:
Abstract:
We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but,
to date, a susceptibility gene in the region has not been identified. We examined data from 3606
SNPs mapping to 10q25-q26 that had been typed in a genome-wide association study (GWAS) of
schizophrenia (479 UK cases/2937 controls). SNPs with p<0.01 (n=40) were genotyped in an
additional 163 UK cases and those markers that remained nominally significant at p<0.01 (n=22)
were genotyped in replication samples from Ireland, Germany and Bulgaria consisting of a total of
1664 cases with schizophrenia and 3541 controls. Only one SNP, rs17101921, was nominally
significant after meta-analyses across the replication samples and this was genotyped in an
additional six samples from the US/Australia, Germany, China, Japan, Israel and Sweden (n=
5142 cases/ 6561 controls). Across all replication samples, the allele at rs17101921 that was
associated in the GWAS showed evidence for association independent of the original data (OR
1.17 (95% CI 1.06-1.29), p=0.0009). The SNP maps 85kb from the nearest gene encoding
fibroblast growth factor receptor 2 (
FGFR2
) making this a potential susceptibility gene for
schizophrenia
Author's Homepage:
http://people.tcd.ie/acorvinhttp://people.tcd.ie/morrisdw
http://people.tcd.ie/mgill
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Molecular Psychiatry;14;
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