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dc.contributor.authorFRODL, THOMAS
dc.contributor.authorDONOHOE, GARY (JAMES)
dc.contributor.authorGILL, MICHAEL
dc.contributor.authorCORVIN, AIDEN PETER
dc.contributor.authorNEWELL, FIONA
dc.contributor.authorROSE, EMMA
dc.contributor.authorFAHEY, CIARA
dc.contributor.authorGARAVAN, HUGH PATRICK
dc.contributor.authorBOKDE, ARUN LAWRENCE WARREN
dc.contributor.authorO'DOHERTY, JOHN PHILIP
dc.contributor.authorMC GRATH, JANE
dc.contributor.authorKELLY, SINEAD
dc.contributor.authorROBERTSON, IAN H
dc.contributor.authorMORRIS, DEREK
dc.date.accessioned2012-02-29T15:27:59Z
dc.date.available2012-02-29T15:27:59Z
dc.date.issued2012
dc.date.submitted2012en
dc.identifier.citationEmma J. Rose, Ciara Greene, Sinead Kelly, Derek W. Morris, Ian H. Robertson, Ciara Fahey, Sarah Jacobson, John O'Doherty, Fiona N. Newell, Jane McGrath, Arun Bodke, Hugh Garavan, Thomas Frodl, Michael Gill, Aiden P. Corvin, Gary Donohoe, The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals, NeuroImage, 60, 1, 2012, 614 622en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/62426
dc.descriptionPUBLISHEDen
dc.description.abstractA common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated how this variation might be mediated at the level of brain structure and function. In healthy individuals (N = 157), voxel based morphometry was used to compare gray matter (GM) volume between homozygous and heterozygous carriers of the `G? allele (i.e. the allele associated with impaired cognition and schizophrenia risk) and homozygous carriers of the non-risk `A? allele. Functional brain imaging data were also acquired from 48 participants during performance of a spatial working memory (SWM) task, and analysed to determine any effect of NOS1 risk status. An a priori region-of-interest analysis identified a significant reduction in ventromedial prefrontal GM volume in `G? allele carriers. Risk carriers also exhibited altered patterns of activation in the prefrontal cortex, caudate, and superior parietal lobe, which were characteristic of abnormal increases in activation in frontoparietal working memory networks and a failure to disengage regions of the default mode network. These functional changes suggest a NOS1-mediated processing inefficiency that may contribute to cognitive dysfunction in schizophrenia. While the mechanisms by which NOS1 may influence brain structure and/or function have not yet been well delineated, these data provide further evidence for a role of NOS1 in risk for schizophrenia via an impact upon cognitive function.en
dc.description.sponsorshipThis work was supported by Science Foundation Ireland (SFI08/IN.1/B1916- Corvin to AC), the Health Research Board (HRA/2009/197 to GD) and the Brain Behavior Research Foundation (formally NARSAD; to GD).en
dc.format.extent614 622en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.ispartofseriesNeuroImage;
dc.relation.ispartofseries60;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectNeuroscienceen
dc.subjectschizophreniaen
dc.titleThe NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individualsen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Irelanden
dc.contributor.sponsorHealth Research Boarden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rosee
dc.identifier.peoplefinderurlhttp://people.tcd.ie/frodlt
dc.identifier.peoplefinderurlhttp://people.tcd.ie/donoghug
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgill
dc.identifier.peoplefinderurlhttp://people.tcd.ie/acorvin
dc.identifier.peoplefinderurlhttp://people.tcd.ie/fnewell
dc.identifier.peoplefinderurlhttp://people.tcd.ie/faheyci
dc.identifier.peoplefinderurlhttp://people.tcd.ie/garavanh
dc.identifier.peoplefinderurlhttp://people.tcd.ie/bokdea
dc.identifier.peoplefinderurlhttp://people.tcd.ie/odoherjp
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sandersj
dc.identifier.peoplefinderurlhttp://people.tcd.ie/iroberts
dc.identifier.peoplefinderurlhttp://people.tcd.ie/morrisdw
dc.identifier.rssinternalid76496
dc.contributor.sponsorGrantNumberSFI08/IN.1/B1916-Corvinen
dc.contributor.sponsorGrantNumberHRA/2009/197en
dc.identifier.rssurihttp://dx.doi.org/10.1016/j.neuroimage.2011.12.054en


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