dc.contributor.author | FALLON, PADRAIC | en |
dc.contributor.author | HAMS, EMILY | en |
dc.contributor.author | AMU, SYLVIE | en |
dc.date.accessioned | 2011-07-07T15:18:12Z | |
dc.date.available | 2011-07-07T15:18:12Z | |
dc.date.issued | 2011 | en |
dc.date.submitted | 2011 | en |
dc.identifier.citation | Emily Hams, Mark J. McCarron, Sylvie Amu, Hideo Yagita, Miyuki Azuma, Lieping Chen and Padraic G. Fallon, Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells, The Journal of Immunology, 186, 10, 2011, 5648-5655 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/57494 | |
dc.description | PUBLISHED | en |
dc.description.abstract | T follicular helper (TFH) cells are critical initiators in the development of T cell-dependent humoral immunity and the generation of protective immunity. We demonstrate that TFH cell accumulation and Ab production are negatively regulated by B7-H1 (programmed death ligand 1) in response to both helminth infection and active immunization. Following immunization of B7-H1?/? mice with keyhole limpet hemocyanin or helminth Ags, there is a profound increase in induction of TFH cells as a result of increased cell cycling and decreased apoptosis relative to wild-type mice. The increase in TFH cells in the absence of B7-H1 was associated with significant elevations in Ag-specific Ig response. Cotransfer experiments in vivo demonstrated that B7-H1 expression on B cells was required for negatively regulating TFH cell expansion and production of Ag-specific Ig. Treatment of immunized wild-type mice with anti?B7-H1 or anti-programmed death 1 mAbs, but not anti?B7-DC, led to a significant expansion of the TFH cell population and an enhanced Ag-specific Ig response. Our results demonstrate that the coinhibitory B7-H1/programmed death 1 pathway can limit the expansion of TFH cells and constrain Ag-specific Ig responses. This finding has direct implications for investigations examining the feasibility of therapeutically manipulating this pathway and reveals new insights into the regulation of the humoral immune response. | en |
dc.description.sponsorship | This work was supported by Science Foundation Ireland (07/IN1/B902), the Health Research Board, and the National Children?s Research Centre. | en |
dc.format.extent | 5648-5655 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | The Journal of Immunology | en |
dc.relation.ispartofseries | 186 | en |
dc.relation.ispartofseries | 10 | en |
dc.rights | Y | en |
dc.subject | Immunology | en |
dc.subject | TFH cells | en |
dc.title | Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells | en |
dc.type | Journal Article | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
dc.contributor.sponsor | Health Research Board (HRB) | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/pfallon | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/hamse | en |
dc.identifier.rssinternalid | 73947 | en |
dc.contributor.sponsorGrantNumber | 07/IN1/B902 | en |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.identifier.rssuri | http://www.jimmunol.org/content/186/10/5648.long | en |