Browsing School of Medicine by Subject "Haemostasis Research Group, Ph.D."

Now showing items 1-3 of 3

    • Modulation of activated protein C (APC) anticoagulant and cytoprotective function 

      Ní Áinle, Fionnuala Bríd (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2011)
      Activated protein C (APC) is an anticoagulant glycoprotein that attenuates thrombin generation. Moreover, it has recently been demonstrated that APC possesses anti-inflammatory, anti-apoptotic and endothelial cell barrier ...

    • Molecular determinants of vitamin K-dependent protease signalling 

      Gleeson, Eimear M. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2013)
      In addition to facilitating fibrin clot formation, a growing body of evidence suggests that coagulation factors play an important role in regulating the innate immune response to infection. Vitamin K-dependent (VKD) proteases ...

    • Role of von Willebrand factor glycans in modulating susceptibility to ADAMTS13 proteolysis 

      McGrath, Rachel (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)
      Von Willebrand factor (VWF) is a large plasma sialoglycoprotein that mediates platelet tethering at sites of vascular injury. VWF adhesive function is dependent upon multimeric composition, which is regulated in plasma by ...