Browsing School of Medicine by Sponsor "National Children's Research Centre"
Now showing items 1-7 of 7
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THE DISTINCT AND AGGRESSIVE PATHOGENESIS OF ARTHRITIS IN CHILDREN WITH DOWN SYNDROME
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Juvenile idiopathic arthritis (JIA) is the most common form of inflammatory arthritis (IA) in children. However, recently we described a more aggressive form of IA in children with Down syndrome (DS), termed Down syndrome ... -
Immunometabolic responses of adult and umbilical cord macrophages to stimulation with Mycobacterium tuberculosis or Lipopolysaccharide
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Tuberculosis (TB) has been the biggest infectious killer in the world in the last decade and young children are among the most vulnerable groups. Mycobacterium tuberculosis (Mtb), the bacteria that causes TB, is phagocytosed ... -
Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorders
Second generation antipsychotics (SGAs) are used in children and adolescents to treat psychotic symptoms in Early Onset Psychosis (EOP) and irritability and behaviours that challenge in autism spectrum disorder (ASD). ... -
An investigation of the role of antenatal depression, maternal cortisol and postnatal interactive behaviour on infant neurodevelopment in the first year of life.
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Abstract Aims: Major Depressive Disorder (MDD) is the most prevalent psychiatric disorder during the perinatal period and can lasting adverse effects on maternal wellbeing and infant development. This aim of this thesis ... -
NEURODEVELOPMENTAL OUTCOME FOR TWINS OF THE ESPRiT STUDY: THE NOTES STUDY
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)THE NOTES STUDY: ABSTRACT Objective: The objective of the NOTES Study was to study the effect of birthweight growth discordance (≥ 20%) on neurodevelopmental outcome and physical growth of monochorionic and dichorionic ... -
SERENITY: SEveRE Neurological Impairment and children with medical complexiTY
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2022)Background and aims Children with Severe Neurological Impairment (SNI) have a significant disability as a result of a global impairment of the nervous system. They may be considered to be a subgroup of children with more ... -
UNICORN; Underlying mechanisms in Neonatal Immune Metabolic Dysregulation and Brain Injury
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction: Neonatal encephalopathy (NE) is a clinically defined syndrome of disturbed neurologic function, in the earliest days of life. NE has a multifactorial aetiology and causes significant mortality and neurological ...