Browsing School of Medicine by Sponsor "Higher Education Authority (HEA)"
Now showing items 1-9 of 9
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Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain
(2011)Abstract: Background: Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial ... -
Correlation of p16(INK4A) expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells.
(2011)Cervical cancer, a potentially preventable disease, has its main aetiology in infection by high risk human papillomavirus (HR-HPV). Approaches to improving cervical cancer screening and diagnostic methodologies include ... -
Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
(2003)Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions ... -
Is "clinical" insight the same as "cognitive" insight in schizophrenia?
(2009)Poor insight is associated with impaired cognitive function in psychosis. Whether poor clinical insight overlaps with other aspects of self-awareness in schizophrenia, such as cognitive self-awareness, is unclear. We ... -
The Molecular Mechanisms of rhIGF1 in the Treatment of Rett Syndrome and Related Disorders: Studies in Patients, Mouse and Cellular Models
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)Recombinant human Insulin-like Growth Factor 1 (rhIGF1) is an approved treatment for growth failure and IGF1 deficiency. IGF1 has multiple functions in the body including growth, cell survival, metabolism, ageing and ... -
Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells
(2011)Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer ... -
The role of nutrition as a determinant of clinical, immunological and pharmacological outcome in HIV-infected children in Uganda
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019)Introduction: Perinatally acquired HIV infection and malnutrition remain major public health challenges for sub-Saharan Africa health systems. HIV and malnutrition result in 50% mortality. The introduction of antiretroviral ... -
The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer
(2010)Prostacyclin synthase and thromboxane synthase signaling via arachidonic acid metabolism affects a number of tumor cell survival pathways such as cell proliferation, apoptosis, tumor cell invasion and metastasis, and ...