Browsing School of Medicine by Sponsor "Enterprise Ireland"
Now showing items 1-7 of 7
-
Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction
(American Society for Biochemistry and Molecular Biology, 2002)T1/ST2 is a member of the interleukin (IL)-1 receptor superfamily, possessing three immunoglobulin domains extracellularly and a Toll/IL1R (TIR) domain intracellularly. The ligand for T1/ST2 is not known. T1/ST2 is expressed ... -
Contralateral selectivity of upper limb motor pools via targeted stimulation of the cervical spinal cord.
(2023)Transcutaneous spinal cord stimulation (tSCS) at the cervical level may facilitate improved upper-limb function in those with incomplete tetraplegia. While clinical trials are ongoing, there is still much debate regarding ... -
Platelet-cancer Cell Interactions induce PAI-1 Expression in an Ovarian Cancer Cell Line Model: Implications for the Metastasis of Epithelial Ovarian Cancer
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2021)This thesis encompasses an investigation into the function of plasminogen activator inhibitor 1 (PAI-1) - a serine protease inhibitor integral to coagulation and fibrinolysis that has been identified as both a key factor ... -
Quantification of unfractionated heparin in human plasma and whole blood by means of novel fluorogenic anti-FXa assays
(Elsevier, 2011)Novel and sensitive plate-based fluorogenic anti-factor Xa (FXa) assays were investigated to quantify unfractionated heparin (UFH) in human plasma and whole blood within the therapeutic ranges of 0-1.6 U/mL and 0?0.8 U/mL, ... -
Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus.
(The American Society for Biochemistry and Molecular Biology, 2005)It is well documented that long term potentiation (LTP) is impaired in the hippocampus of the aged animal. Among the changes that contribute to this impairment is an increase in hippocampal concentration of the pro-inflammatory ... -
Transcutaneous spinal cord stimulation and motor responses in individuals with spinal cord injury: A methodological review
(2021)Background Transcutaneous spinal cord stimulation (tSCS) is a non-invasive modality in which electrodes can stimulate spinal circuitries and facilitate a motor response. This review aimed to evaluate the methodology of ... -
Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1 beta in a new murine model for analysis of neuronal side effects of vaccination
(American Society for Microbiology, 2001)Immunization with the whole-cell pertussis vaccine (Pw), while effective at preventing whooping cough in infants, has been associated with local, systemic, and neuronal reactions, including fevers and convulsions in children. ...