Browsing School of Medicine by Title
Now showing items 344-363 of 3129
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C-ABL in human cancer: an investigation of its role in apoptosis inhibition, differentiation and angiogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2003)Research over the past number of decades has significantly advanced our understanding of the cell signalling effects that mediate a diverse array of cellular activities including cell proliferation, homeostasis and ... -
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
(American Society for Biochemistry and Molecular Biology, 2004)The amyloid precursor protein (APP) is proteolytically processed to release a C-terminal domain that signals to the nucleus to regulate transcription of responsive genes. The APP C terminus binds to a number of phosphotyrosine ... -
C-reactive protein as a prognostic factor in cancer
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2022)Prognostication, the prediction of future outcomes, is a key aspect of cancer care but remains imprecise. An elevated serum C-reactive protein (CRP) is associated with high symptom burden, poor quality of life and shorter ... -
The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection
(American Society for Microbiology, 2009)The de novo immune response to infectious organisms arises from the innate recognition of pathogen-associated molecular patterns (PAMPs) by the host's pattern recognition receptors (PRRs). As the generation of type 2 ... -
C3 glomerulopathy: consensus report.
(2013)C3 glomerulopathy is a recently introduced pathological entity whose original definition was glomerular pathology characterized by C3 accumulation with absent or scanty immunoglobulin deposition. In August 2012, an invited ... -
C5L2, a nonsignalling C5A receptor is uncoupled to G proteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The complement anaphylatoxins are prominent mediators of host defence and inflammation. The small subunit of the fifth component of complement, C5a has complex effects in vivo including potential anti- and pro-inflammatory ... -
A cadaveric dissection study of the anatomical variations of the ureter and implications for surgical intervention
(Trinity College Dublin. School of Medicine. Discipline of Anatomy, 2019)A cadaveric dissection study of the anatomical variations of the ureter and implications for surgical intervention Joan M. Costelloe The importance of studying ureteric anatomy such that it can be applied to surgical ... -
Calculating the costs of an 8-week, physiotherapy-led exercise intervention in deconditioned cancer survivors in the early survivorship period (the PEACH trial)
(2014)Strong evidence exists for rehabilitation programmes following a cancer diagnosis, although little is known about their cost. The effects of an 8-week, physiotherapy-led, structured group intervention during the early ... -
Can a practice pharmacist improve prescribing safety and reduce costs in polypharmacy patients? A pilot study on an intervention in an Irish general practice setting
(2022)Objectives: This study aimed to develop and assess the feasibility and cost impact of an intervention involving a practice pharmacist embedded in general practice to improve prescribing safety, deprescribe where appropriate ... -
Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?
(2018)AIM: To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori (H. pylori)-infected patients in Ireland. METHODS: DNA was extracted from antral and corpus biopsies ... -
Can the systematic use of non-invasive biomarkers in patients with lower gastrointestional sysmtpoms help rationalise the demand for limited endoscopy resources?
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Introduction: Gastrointestinal complaints are very common in the general population. Demand for endoscopy continues to outstrip capacity, despite significant annual increase in the number of endoscopies performed nationwide, ... -
Cancer Cachexia - Prevalence and Predictors in Treatment-naive Patients
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Title: Cancer Cachexia Prevalence and Predictors in Treatment-naïve Patients Candidate Name: Dr Niamh O Donoghue Background Cancer cachexia is a common wasting syndrome, yet it remains poorly understood and under-recognised. ... -
Cancer Cachexia:Mechanisms and Clinical Implications
(Hindawi, 2011)Cachexia is amultifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. It is associated with poor quality of life, poor physical function, and poor prognosis in cancer ... -
Cancer cell-platelet interactions in ovarian cancer metastasis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Ovarian cancer is the leading cause of death from gynaecological malignancy worldwide with an estimated global incidence of 225,900 and mortality of 140,200 per year. In Ireland ovarian cancer is the second most common ... -
Cancer risks for BRCA1 and BRCA2 mutation carriers: Results from prospective analysis of EMBRACE
(2013)Background Reliable estimates of cancer risk are critical for guiding management of BRCA1 and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for breast cancer, ovarian cancer, ... -
Cancer stemness : unravelling the molecular mechanisms controlling stem cell differentiation and self-renewal
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Understanding the molecular mechanisms behind cancer cell proliferation and regulation is the key to discovering potential future successful therapies for cancer. The World Health Organisation estimates that 7.6 million ... -
Cancer Symptom Clusters: An Exploratory Analysis of Eight Statistical Techniques
(2014)PURPOSE: Low serum 25-hydroxyvitamin D [25(OH)D] levels have been linked to both cancer incidence and poor prognosis. The frequency of 25(OH)D tests and clinical factors associated with low levels in cancer patients are ...