Browsing School of Medicine by Title
Now showing items 277-296 of 3129
-
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.
(2010)Although B-Raf(V600E) is the most common somatic mutation in papillary thyroid carcinoma (PTC), how it induces tumor aggressiveness is not fully understood. Using gene set enrichment analysis and in vitro and in vivo ... -
Bacterial self-defence: how Escherichia coli evades serum killing.
(2014)The ability to survive the bactericidal action of serum is advantageous to extraintestinal pathogenic Escherichia coli that gain access to the bloodstream. Evasion of the innate defences present in serum, including complement ... -
Balance and Physical Functioning in Patients After Head and Neck Cancer Post?Neck Dissection Surgery: A Case Series.
(2020)Background and Purpose: Rehabilitation research in people with head and neck cancer, undergoing neck dissection (ND) surgery, has been largely confined to evaluation of shoulder dysfunction. Balance and broader ... -
Barrett's oesophagus and associated cancer : the influence of bile acid regulated genetic factors and intestinal transcription factors in the pathogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)Gastrooesophageal reflux disease (GORD) is very common and it is estimated that up to 20% of the western population will experience weekly heartburn. The initial simple mucosal damage can lead to further complications like ... -
Barriers and facilitators to adoption, implementation and sustainment of obesity prevention interventions in schoolchildren - a DEDIPAC case study
(2019)Background: The aim of the study was to explore the implementation of school based diet and physical activity interventions with respect to the barriers and facilitators to adoption, implementation and sustainability; ... -
Barriers and facilitators to implementation of menu labelling interventions from a food service industry perspective: A mixed methods systematic review
(BMC, 2020)BACKGROUND: Eating outside the home contributes to poor dietary habits worldwide and is associated with increased body fat and weight gain. Evidence shows menu labelling is effective in promoting healthier food choices; ... -
Barriers and facilitators to implementation of menu labelling interventions to support healthy food choices: a mixed methods systematic review protocol
(2018)Background: Menu labelling is continuing to gather public and legislative support as one of the potential environmental strategies for addressing the obesity pandemic. However, issues relating to implementation have been ... -
Barriers and facilitators to the implementation of an early intervention in psychosis service in three demonstration sites in Ireland
(2023)Background: Programmes for early intervention (EIP) in psychosis for people experiencing a first episode of psychosis (FEP) have been found to be both clinically and cost effective. Following the publication of a new EIP ... -
Barriers to accessing aeroallergen immunotherapy in paediatrics
(2023)Background: Allergen immunotherapy (AIT) is a safe, effective and disease-modifying treatment for allergic rhinitis. It is indicated for children with moderate to severe disease whose symptoms persist despite conventional ... -
Basal forebrain volume, but not hippocampal volume, is a predictor of global cognitive decline in patients with alzheimer's disease treated with cholinesterase inhibitors
(2018)Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes ... -
Bcl11b is essential for group 2 innate lymphoid cell development
(2015)Group 2 innate lymphoid cells (ILC2s) are often found associated with mucosal surfaces where they contribute to protective immunity, inappropriate allergic responses, and tissue repair. Although we know they develop from ... -
Bcr-Abl regulates osteopontin transcription via Ras, PI-3K, aPKC, Raf-1 and MEK
(2005)Chronic myeloid leukemia (CML) is caused by the constitutively active Bcr-Abl tyrosine kinase. This fusion protein is generated by the Philadelphia translocation t(9;22). CML is a progressive condition that invariably ... -
Bcr-Abl regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation is required for proliferation and drug resistance
(2006)The BCR-ABL oncogene is the hallmark of chronic myeloid leukemia, a clonal hematopoietic stem cell disorder. BCR-ABL displays constitutive tyrosine kinase activity, required for its transformation ability. Although the ... -
BDNF-stimulated intracellular signalling mechanisms underlie exercise-induced improvement in spatial memory in the male Wistar rat.
(2014)Exercise-induced improvements in learning are associated with neurotrophic and neurogenic changes in the dentate gyrus, but the intracellular signalling mechanisms that may mediate these improvements remain unknown. In the ... -
Before and after study of bar workers' perceptions of the impact of smoke-free workplace legislation in the Republic of Ireland
(BioMed Central, 2007)BACKGROUND: Objectives: To compare support for, and perceptions of, the impacts of smoke-free workplace legislation among bar workers in the Republic of Ireland (ROI) pre- and post-implementation, and to identify predictors ...
