Browsing School of Medicine by Title
Now showing items 41-60 of 3153
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A surgical delivery system for targeted cancer gene therapy : the potential therapeutic role of genetically modified microvascular free flaps in the management of primary tumours
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Gene therapy has generated interest for the treatment of soft tissue malignancies. It offers the theoretical promise of delivering cytotoxic, immunomodulatory, or anti- angiogenic genes to produce proteins targeting tumour ... -
A therapeutic roadmap for ovarian cancer using TLR4 MyD88 and MAD2 as prognostic indicators
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2016)Ovarian cancer is 4th leading cause of cancer death in woman and the most lethal gynaecological malignancy. Most patients present with advanced disease where the 5 year survival rate is less than 40%. Standard treatment ... -
Abnormal functional connectivity during visuospatial processing is associated with disrupted organisation of white matter in autism.
(2013)Disruption of structural and functional neural connectivity has been widely reported in Autism Spectrum Disorder (ASD) but there is a striking lack of research attempting to integrate analysis of functional and structural ... -
Abnormal functional connectivity in autism spectrum disorder is associated with disrupted white matter microstructural organisation
(2013)Disruption of structural and functional neural connectivity has been widely reported in Autism Spectrum Disorder (ASD) but there is a striking lack of research attempting to integrate analysis of functional and structural ... -
Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.
(2010)Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases, such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes with specific brain functions. Under these ... -
ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a metanalysis
(2021)Background Hypertension and type 2 diabetes increase the risk of severe SARS-CoV-2 infection. On the other hand, homozygous ACE deletion polymorphism (DD) has been associated with these two diseases and risk of acute ... -
Acidosis at birth in term infants and early neurophysiological and cardiovascular changes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2005)This thesis was mounted to evaluate and quantify the role of umbilical cord pH measurements in relation to the baby’s clinical condition, electroencephalographic pattern, heart rate variability and analysis of sucking ... -
Acidosis significantly alters immune checkpoint expression profiles of T cells from oesophageal adenocarcinoma patients
(2023)Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of acidosis on anti-tumour T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study ... -
Activated Factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine prodution from LPS-stimulated myeloid cells.
(2014)Vitamin K-dependent proteases generated in response to vascular injury and infection enable fibrin clot formation, but also trigger distinct immuno-regulatory signaling pathways on myeloid cells. Factor Xa, a protease ... -
Activating CARD14 Mutations Are Associated with Generalized Pustular Psoriasis but Rarely Account for Familial Recurrence in Psoriasis Vulgaris.
(2015)Caspase recruitment family member 14 (CARD14, also known as CARMA2), is a scaffold protein that mediates NF-κB signal transduction in skin keratinocytes. Gain-of-function CARD14 mutations have been documented in familial ... -
Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response
(2016)Apoptosis is a highly regulated cellular process that functions to remove undesired cells from multicellular organisms. This pathway is often disrupted in cancer, providing tumours with a mechanism to avoid cell death and ... -
Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus
(2003)Lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria, has been shown to induce profound changes both peripherally and centrally. It has recently been reported that intraperitoneal injection of ... -
Active case finding of tuberculosis in Europe: a Tuberculosis Network European Trials Group (TBNET) survey
(2008)Tuberculosis control depends on successful case finding and treatment of individuals infected with Mycobacterium tuberculosis. Passive case finding is widely practised: the present study aims to ascertain the consensus and ... -
Active video games as a form of exercise and the effect of gaming experience: a preliminary study in healthy young adults.
(2012)Objectives: To examine the energy expenditure and heart rate response while playing active video games, and the effect of gaming experience on energy expenditure. Design: Cross-sectional study. Participants and ... -
Active video games as an exercise tool for children with cystic fibrosis.
(2013)Background: Active video games are used in many hospitals as exercise tools for children with cystic fibrosis. However, the exercise intensity associated with playing these games has not been examined in this population. Methods: ... -
Acute Stroke Care in Ireland - The Role of a National Audit in Improving Care
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Background: The 2008 Irish national audit of stroke service (INASC) showed large deficits in service provision and access. A national stroke programme emerged to develop services and address these deficits. The country ... -
Acute urinary retention in a young man secondary to colonic irrigation: a case report
(BioMed Central, 2009)Introduction Autonomic innervation of the bladder is complex and regulated by a hierarchy of mechanisms of the central nervous system. Any dysfunction in these regulatory mechanisms can lead to acute urinary retention. Case ...