Browsing School of Medicine by Title
Now showing items 364-383 of 3152
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Cancer stemness : unravelling the molecular mechanisms controlling stem cell differentiation and self-renewal
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Understanding the molecular mechanisms behind cancer cell proliferation and regulation is the key to discovering potential future successful therapies for cancer. The World Health Organisation estimates that 7.6 million ... -
Cancer Symptom Clusters: An Exploratory Analysis of Eight Statistical Techniques
(2014)PURPOSE: Low serum 25-hydroxyvitamin D [25(OH)D] levels have been linked to both cancer incidence and poor prognosis. The frequency of 25(OH)D tests and clinical factors associated with low levels in cancer patients are ... -
Cancer-related insomnia
(2014)Insomnia increases cancer symptom burden and impairs quality of life. The lack of standard definitions and treatment guidelines makes management difficult. Insomnia is common in most cancers but appears particularly so in ... -
Candidate role for TLR3 L412F in disease progression in Idiopathic Pulmonary Fibrosis (IPF) during bacterial and viral infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)In this thesis, we investigated the mechanisms by which TLR3 Leu412Phe (L412F) promotes disease progression in idiopathic pulmonary fibrosis (IPF) patients. IPF is a fatal interstitial lung disease of unknown aetiology and ... -
A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis
(2013)Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but ... -
The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health.
(2013)Significant loss of bone due to trauma, underlying metabolic disease, or lack of repair due to old age surpasses the body’s endogenous bone repair mechanisms. Mesenchymal stem cells (MSCs) are adult stem cells which may ... -
Capsule endoscopy with artificial intelligence-assisted technology: Real-world usage of a validated AI model for capsule image review
(2023)Background and study aims Capsule endoscopy is a time-consuming procedure with a significance error rate. Artificial intelligence (AI) can potentially reduce reading time significantly by reducing the number of images ... -
Carbohydrate versus caffeinated-carbohydrate beverages: effects on exercise performance and hydration status at rest and during exercise
(Trinity College (Dublin, Ireland). Department of Physiology, 2007)Carbohydrate versus caffeinated-carbohydrate beverages: effects on exercise performance and hydration status at rest and during exercise. The consumption of sports drinks to enhance athletic performance had been the subject ... -
Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells
(2014)A major risk factor for ovarian cancer is germline mutations of BRCA1/2. It has been found that (80%) of cellular models with acquired platinum or taxane resistance display an inverse resistance relationship, that is ... -
Cardiovascular associations of falls and syncope in the elderly
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2017)The principle aims of this doctoral investigation are to provide new insights into the relationship between cardiovascular disease (CVD) and falls in the elderly population in Ireland. The rapidly ageing global demographic ... -
Cardiovascular Autonomic Nervous System, Blood Pressure Instability and Brain Health in Older Adults: Population-Based Perspectives
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2019)The aim of this thesis is to provide new insights into the shared pathways by which the cardiovascular autonomic nervous system underpins optimal regulation of affect and cognitive function in older adults. Ageing is ... -
Cardiovascular Control during Exercise in Type 2 Diabetes Mellitus
(2015)Controlled studies of male and female subjects with type 2 diabetes mellitus (DM) of short duration (~3–5 years) show that DM reduces peak (L·min−1 and mL·kg−1·min−1) by an average of 12–15% and induces a greater slowing ... -
Cardiovascular Health in Professional Rugby Union Athletes
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2021)Cardiovascular disease (CVD) defines a class of diseases relating to the heart and blood vessels, including coronary heart disease, coronary artery disease and hypertension. CVD risk and outcomes can be managed through ... -
Cardiovascular risk and systemic inflammation in male professional rugby: a cross-sectional study
(2023)Objective To investigate cardiovascular risk factors’ prevalence and association with systemic inflammation in professional male rugby players (RP). Methods A cross-sectional investigation of 46 professional male RP ... -
Cardiovascular risk factors and frailty in a cross-sectional study of older people: implications for prevention.
(2018)Objective: to examine the associations of cardiovascular disease (CVD) and cardiovascular risk factors with frailty. Design: a cross-sectional study. Setting: the Irish Longitudinal Study on Ageing (TILDA). Participants: ... -
Cardiovascular risk in non-diabetes mellitus insulin resistant states
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2012)This thesis explores the various cardiovascular risks that occur in insulin resistant states apart from type 2 diabetes mellitus (T2DM). Various cardiovascular risk markers and metabolic derangements related to cardiovascular ...