Browsing School of Medicine by Title
Now showing items 297-316 of 3152
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BDNF-stimulated intracellular signalling mechanisms underlie exercise-induced improvement in spatial memory in the male Wistar rat.
(2014)Exercise-induced improvements in learning are associated with neurotrophic and neurogenic changes in the dentate gyrus, but the intracellular signalling mechanisms that may mediate these improvements remain unknown. In the ... -
Before and after study of bar workers' perceptions of the impact of smoke-free workplace legislation in the Republic of Ireland
(BioMed Central, 2007)BACKGROUND: Objectives: To compare support for, and perceptions of, the impacts of smoke-free workplace legislation among bar workers in the Republic of Ireland (ROI) pre- and post-implementation, and to identify predictors ... -
Behavioural change in relation to alcohol exposure in early pregnancy and impact on perinatal outcomes--a prospective cohort study.
(2013)Background There has been limited research addressing whether behavioural change in relation to alcohol exposure in pregnancy results in better perinatal outcomes. Methods A cohort study of 6725 women who booked for ... -
Bereavement and people with intellectual disabilities
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2007)For most people, the loss of a loved one is a tragedy unequalled by any other. It affects every family and raises policy and logistic issues for the health and social service agencies of every community. Currently, people ... -
Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide
(2004)The mechanisms underlying the inhibition of long-term potentiation (LTP) induction by amyloid -peptide (A ) were investigated in the medial perforant path of the rat and mouse dentate gyrus in vitro . Evidence ... -
Beta₂-adrenoceptor modulation of the inflammatory response induced by thrombin and amyloid-beta in glial cells
(Trinity College (Dublin, Ireland). Department of Physiology, 2010)Thrombin is a blood protein that leaks into the brain parenchyma when the blood- brain barrier is damaged, and has been implicated in the neuropathology associated with stroke, traumatic brain injury and Parkinson’s disease ... -
Beta₂-adrenoceptors as modulators of glial immune function
(Trinity College (Dublin, Ireland). Department of Physiology, 2009)The endogenous anti-inflammatory and neurotrophic effects of noradrenahne are mediated by β2-adrenoceptors on astrocytes and microglia in the central nervous system (CNS). Notably, clinical studies demonstrate that ... -
Bile acids and Barrett's oesophagus : the development of a functional siRNA screen to identify novel therapeutic targets
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The development of oesophageal adenocarcinoma (OAC) occurs in a setting of chronic reflux known as gastro-oesophageal reflux disease (GORD) and with a recognised premalignant lesion, Barrett’s oesophagus (BO). BO is ... -
Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells.
(2010)Deoxycholic acid (DCA) is a secondary bile acid that modulates signalling pathways in epithelial cells. DCA has been implicated in pathogenesis of colon carcinoma, particularly by activation of the protein kinase C (PKC) ... -
Bimodal magnetic-fluorescent nanostructures for biomedical applications
(2009)Magnetite-based polyelectrolyte-coated nanostructures were fabricated and the potential for biomedical application assessed in mixed glial cell cultures with nanostructure cellular internalization, cytotoxicty and contribution ... -
Bio-collections in autism research.
(2017) -
Bioinformatic and Genetic Association Analysis of MicroRNA Target Sites in One-Carbon Metabolism Genes.
(2011)One-carbon metabolism (OCM) is linked to DNA synthesis and methylation, amino acid metabolism and cell proliferation. OCM dysfunction has been associated with increased risk for various diseases, including cancer and neural ... -
Biological Characteristics of Gastroesophageal Junction Adenocarcinomas and their Clinical Correlates
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Gastroesophageal junction adenocarcinomas (GEJA) have increased in incidence in the Western world over the last 50 years, a trend largely attributed to lifestyle factors including obesity and gastroesophageal reflux disease. ... -
Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants.
(2014)Objective Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share genetic risks. The aim of this analysis was to determine more broadly whether ADHD and ASD share ... -
Biomarker discovery in non-small cell lung cancer
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)In Ireland, lung cancer represents the third most common cancer, after breast and prostate cancer. Major improvements have been made in treating this disease with the advent of targeted therapies and immunotherapy. These ... -
Biomarker Signatures of Two Phenotypical Pre-Frailty Types in The Irish Longitudinal Study on Ageing
(2022)Abstract: We investigated the biomarker signatures of two previously reported phenotypical prefrailty (PF) types in the first wave of The Irish Longitudinal Study on Ageing (TILDA): PF1 (unexplained weight loss and/or ...