Browsing School of Medicine by Title
Now showing items 2623-2642 of 3152
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The role and treatment potential of natural killer T (NKT) cells in patients with upper gastrointestinal cancers
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2019)Oesophageal adenocarcinoma (OAC), squamous cell carcinoma (SSC) and gastric cancers (GAC), collectively cause over 1.3 million deaths worldwide reported in 2018. Current therapeutic regimens focus on chemo-radiotherapy ... -
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis.
(2013)Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors and infiltrate the skin after allergen challenge, where they produce ... -
A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.
(2011)Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. ... -
The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Title : The role of angiopoietins and their mediators in symptomatic small bowel angiodysplasia; identifying novel diagnostic and therapeutic targets in chronic anaemia and obscure gastrointestinal bleeding. Author: Dr ... -
The role of canonical and non-canonical inflammasomes in a model of oxidative stress-induced retinal degeneration
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Retinal degenerative diseases like age-related macular degeneration (AMD) are a leading cause of visual impairment. Oxidative stress is known to be important in the pathogenesis of AMD, and oxidative-stress induced retinal ... -
The role of chemokines in acute and chronic hepatitis C infection.
(2014)Hepatitis C imposes a significant burden on global healthcare. Chronic infection is associated with progressive inflammation of the liver which typically manifests in cirrhosis, organ failure and cancer. By virtue of ... -
The role of eHealth to promote physical activity in people with cancer.
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2020)The role of eHealth to promote physical activity in people with cancer. Ciar?n Haberlin BSc (Physiotherapy), P.Grad. Cert (Clinical Exercise) Background Exercise and physical activity (PA) are established and effective ... -
The role of endotoxin/lipopolysaccharide in surgically induced tumour growth in a murine model of metastatic disease
(Nature Publishing Group, 1999)Surgical removal of a primary tumour is often followed by rapid growth of previously dormant metastases. Endotoxin or lipopolysaccharide, a cell wall constituent of Gram-negative bacteria, is ubiquitously present in air ... -
The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic environments
(2015)Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and an - giogenic microenvironments by supporting disease progression in a range of disease entities. To adapt to fluctuating st ... -
?The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic microenvironments'.
(2015)Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and angiogenic microenvironments by supporting disease progression in a range of disease entities. To adapt to fluctuating stress-induced ... -
The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ... -
The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer
(2011)Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ... -
The Role of EUS and Proteomic Analysis in the Management and Surveillance of Pancreatic Cystic Lesions
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Pancreatic cystic lesions (PCL) can be precursors to pancreatic cancer. The incidence of PCL are increasing worldwide with increased patient age and reliance on cross sectional imaging. However, not all PCL ... -
The Role of Exercise Prehabilitation Prior to Oncological Resection
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2024)Cancer is characterised by uncontrolled cell growth within the body. Surgical resection is the primary curative treatment for solid tumours. However, surgery is invasive and associated with significant morbidity and ... -
The role of FKBP5 genetics and epigenetics in mediating the effects of early life adversity on emotional processing brain regions in major depressive disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)Major depressive disorder (MDD) is the most widespread psychiatric illness and is characterized by loss of pleasure, depressed mood, sleep disturbances and anxiety. Recently, an inflammatory theory of MDD has emerged, which ... -
The role of GPR55 in neuronal and immune cell signalling and function
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)The orphan G-protein coupled receptor, GPR55, is widely expressed throughout the body and is responsive to cannabinoids. However, its endogenous ligand is believed to be L-a-lysophosphatidylinositol (LPI). GPR55 is expressed ... -
The role of inflammation in cancer of the esophagus.
(2014)Esophageal adenocarcinoma is the eighth most common malignancy worldwide. The overall prognosis is poor, with 5-year survival ranges of approximately 15-25%, and 30-50% for patients who can be treated with curative intent. ... -
The role of innate lymphocyte metabolism in sepsis
(Trinity College Dublin. School of Medicine. Discipline of Immunology, 2020)Sepsis is the result of a dysregulated systemic immune response to microbial infection that leads to organ failure and death in about 30% of affected individuals. The antimicrobial response is biphasic with an overwhelming ... -
Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus.
(The American Society for Biochemistry and Molecular Biology, 2005)It is well documented that long term potentiation (LTP) is impaired in the hippocampus of the aged animal. Among the changes that contribute to this impairment is an increase in hippocampal concentration of the pro-inflammatory ... -
The role of intermediaries in connecting community-dwelling adults to local physical activity and exercise: a scoping review
(2023)Introduction/Purpose Physical inactivity has been declared a global pandemic by the World Health Organization. Methods to connect inactive individuals from healthcare settings to physical activity include brief interventions ...