Browsing School of Medicine by Title
Now showing items 2461-2480 of 3152
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A prospective cohort study of alcohol exposure in early and late pregnancy within an urban population in Ireland
(2014)Most studies of alcohol consumption in pregnancy have looked at one time point only, often relying on recall. The aim of this longitudinal study was to determine whether alcohol consumption changes in early and late pregnancy ... -
Prospective cohort study of hospital inpatients with advanced cancer : cost analysis of a palliative care consultation team intervention
(Trinity College (Dublin, Ireland). School of Medicine. Centre of Health Policy and Management, 2015)The provision of care to people living and dying with serious chronic illness is a public health priority in most parts of the world. In a context of demographic change and shifting patterns of disease, the cost of care ... -
A prospective evaluation of bone mineral density measurement in females who have fallen
(2003)Background: the National Service Framework for Older Persons recognises the relationship between falls and osteoporosis; however, the best method for the evaluation of bone mineral density measurement in fallers is unclear. ... -
A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers
(2013)Background Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the ... -
A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers
(2013)Background Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the ... -
Prospective observational cohort study of 'treatment as usual' over four years for patients with schizophrenia in a national forensic hospital.
(2018)Background: We evaluated change in response to multi-modal psychosocial ‘treatment as usual’ programs offered within a forensic hospital. Methods: Sixty nine patients with a diagnosis of schizophrenia or schizoaffective ... -
Prospective Study of a Novel Diagnostic Algorithm for Investigating and Managing Gastrointestinal Disease Through The Appropriate Use of Biomarkers and Wireless Based Capsule Endoscopy
This chapter gives a general outline of the thesis for better understanding of issues surrounding research areas and studies that have been performed. Lower Gastrointestinal (GI) Symptoms are common and often warrant further ... -
Prospective study of factors influencing conditional discharge from a forensic hospital: the DUNDRUM-3 programme completion and DUNDRUM-4 recovery structured professional judgement instruments and risk
(2013)Background We set out to examine whether structured professional judgement instruments DUNDRUM-3 programme completion (D-3) and DUNDRUM-4 recovery (D-4) scales along with measures of risk, mental state and global function ... -
A Prospective Study of the Clinical Content of Palliative Medicine Interdisciplinary Team Meetings
(2014)Structured interprofessional communication should improve the structure and clarity of the plan of care. The interdisciplinary team meeting (IDTM) is an opportunity for shared information on patients' and family care needs. ... -
A prospective, real-world, multinational study of naloxegol for patients with cancer pain diagnosed with opioid-induced constipation - the NACASY Study
(2022)The Naloxegol Cancer Study (NACASY) was a multinational European study aimed to evaluate the 4-week safety and efficacy of naloxegol in a real-world setting in patients with cancer pain diagnosed with opioid-induced ... -
Prostate cancer pharmacoepidemiology : digoxin, aspirin and patient outcomes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2013)Pharmacoepidemiology is the study of the effects of medicines in a real-world population; combining pharmacology, the study of medicines, with epidemiology the study of diseases. Prostate cancer is the most commonly diagnosed ... -
Prostate cancer progression to androgen independence - do changes in the androgen receptor CAG repeat number play a role?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2007)Prostate cancer is the commonest non-cutaneous male malignancy and is the second commonest cause of cancer-related deaths in many Western countries. Approximately half of all men diagnosed with prostate cancer will have ... -
Protection against ß-amyloid-induced synaptic and memory impairments via altering ß-amyloid assembly by bis(heptyl)-cognitin
(2015)β-amyloid (Aβ) oligomers have been closely implicated in the pathogenesis of Alzheimer’s disease (AD). We found, for the first time, that bis(heptyl)-cognitin, a novel dimeric acetylcholinesterase (AChE) inhibitor derived ... -
The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure
(Springer Paris, 2017)Background Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could ... -
The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell deat
(2014)The parkin-associated endothelial-like receptor (PAELR, GPR37) is an orphan G protein-coupled receptor that interacts with and is degraded by parkin-mediated ubiquitination. Mutations in parkin are thought to result in ... -
Protein Kinase C : a key enzyme in mediating interferon-a signalling and a new player in its activity against Hepatitis C infection
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)The hepatitis C virus (HCV) is a major cause of chronic liver cirrhosis and hepatocellular carcinoma (Lauer and Walker, 2001). The World Health Organisation estimates that there are 170 million individuals infected globally, ... -
Protein Kinase C Beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival
(2016)Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ... -
?Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival?.
(2016)Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ... -
Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease
(2013)Post-translational modification of proteins by deamidation or transamidation by tissue transglutaminase (tTG) has been suggested as a possible mechanism for the development of autoimmunity. Sequence analysis of protein ...