Browsing School of Medicine by Title
Now showing items 2023-2042 of 3152
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Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease
(Elsevier, 2010)Magnetic resonance imaging (MRI)-based volumetry of medial temporal lobe regions is among the best established biomarker candidates of Alzheimer's disease (AD) to date. This study assessed the effect of multicentre variability ... -
Multidisciplinary Rehabilitation in Oesophago-gastric Cancer Surviorship
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2018)As survival rates for oesophageal and gastric cancer slowly improve, there has been an emergence of a unique cohort of cancer survivors who present with multifaceted nutritional and physical needs which are amenable to ... -
The multifunctional role of filaggrin in allergic skin disease.
(2013)Filaggrin is a major structural protein in the stratum corneum of the epidermis. Mutations in the filaggrin gene are the most significant known genetic risk factor for the development of atopic dermatitis. Mutations in the ... -
Multifunctional specificity of the protein C/activated protein C Gla domain.
(American Society for Biochemistry and Molecular Biology, 2006)Activated protein C (APC) has potent anticoagulant and anti-inflammatory properties that are mediated in part by its interactions with its cofactor protein S and the endothelial cell protein C receptor (EPCR). The protein ... -
Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs
(2018)Evidence supports the advantages of inhalation over other drug-administration routes in the treatment of lung diseases, including cancer. Although data obtained from animal models and conventional in vitro cultures are ... -
Multimodal Analysis for Brain Network Fingerprints in Parkinson's Disease Patients
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Parkinson's disease is a neurodegenerative disorder that causes structural and functional abnormalities in the central nervous system. The disease leads to the development of cardinal motor symptoms, including bradykinesia, ... -
Multimodal Approach to Endophenotype Discovery in Disorders with Genetic Liability
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Neurodevelopmental and Neurodegenerative disorders constitute a huge weight on society in terms of human suffering and economic cost. In recent years an increasing amount of emphasis has been placed on investigating the ... -
Multimorbidity in younger deprived patients: an exploratory study of research and service implications in general practice
(BioMed Central, 2008)Multimorbidity has been defined as the co-existence of two or more chronic conditions. It has a profound impact on both the individuals affected and on their use of healthcare services. The limited research to date has ... -
Multinational Association of Supportive Care in Cancer (MASCC) expert opinion / guidance on the use of clinically-assisted hydration in patients with advanced cancer
(2024)Purpose: The provision of clinically assisted hydration (CAH) in patients with advanced cancer is controversial, and there is a paucity of specific guidance and so a diversity in clinical practice. Consequently, the ... -
Multinational Association of Supportive Care in Cancer (MASCC) expert opinion/guidance on the use of clinically assisted nutrition in patients with advanced cancer
(2022)Purpose: The pro vision of clinically assisted nutrition (CAN) in patients with advanced cancer is controversial, and there is a paucity of specific guidance, and so a diversity in clinical practice. Consequently, the ... -
Multiparametric evaluation of magnetic nanoparticles for theranostic applications in breast and pancreatic cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2016)Magnetic iron oxide nanoparticles (MNP) are superparamagnetic below 30 nm in size, have high surface to volume ratio in the nanometre size range, display no remnant magnetism in the absence of a magnetic field yet have ... -
Multiparametric MRI study of ALS stratified for the C9orf72 genotype
(2013)Objective: To describe the patterns of cortical and subcortical changes in amyotrophic lateral sclerosis (ALS) stratified for the C9orf72 genotype. Methods: A prospective, single-center, single-protocol, gray and ... -
Multiple common variants for celiac disease influencing immune gene expression
(2010)We performed a second-generation genome-wide association study of 4,533 individuals with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with P(GWAS) < 10(-4) and 18 SNPs from 14 known ... -
A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD).
(2011)Introduction Although there is evidence for distinct behavioural sub-phenotypes in Alzheimer's disease (AD), their inter-relationships and the effect of clinical variables on their expression have been little ... -
Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer s Disease
(PLoS, 2011)The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, ... -
Multiple medication use in the middle and older age population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2013)Polypharmacy in the older population is increasingly common and can represent necessary preventative therapies or potential inappropriate prescribing and be a risk factor for falls. In addition, medications with anti-cholinergic ... -
Multiple norovirus infections in a birth cohort in a Peruvian peri-urban community.
(2014)Human noroviruses are among the most common enteropathogens globally, and are a leading cause of infant diarrhea in developing countries. However, data measuring the impact of norovirus at the community level are ... -
Multiple sclerosis in Ireland : costs, health-related quality of life and cost effectiveness of disease-modifying therapies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2014)This study aimed to evaluate the economic and health-related quality of life (HRQoL) burden of multiple sclerosis (MS) in Ireland, and to develop a framework for assessing the cost effectiveness of disease-modifying therapies ...