Browsing School of Medicine by Title
Now showing items 1736-1755 of 3153
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Investigations into Pyrrolo-1,5-Benzoxazepine-15-induced apoptosis of chronic B-cell malignancies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2009)Multiple myeloma and chronic lymphocytic leukaemia (CLL) are chronic B-cell malignancies, which are characterised by the accumulation of malignant cells with low proliferative capacity and defective apoptotic mechanisms. ... -
Investigations into the role of mast cell mediated effects on the intestinal epithelial barrier in vitro : implications for the pathogenesis of irritable bowel syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2013)Irritable bowel syndrome (IBS) is a highly prevalent functional bowel disorder characterised by abdominal pain or discomfort and associated with altered bowel habit, abdominal bloating and disturbed defecation. The aetiology ... -
Investigations of Aspergillus infection in Cystic Fibrosis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2015)Aspergillus fumigatus is a ubiquitous saprophytic fungus that is a pathogen in principally immunocompromised hosts. It is the most common fungal pathogen in Cystic Fibrosis (CF), most often associated with Allergic ... -
Involving older people in co-designing a primary-care intervention to reverse frailty and build resilience
(2021)Background: An essential consideration in health research is to conduct research with members of the public rather than for them. Public and patient involvement (PPI) of older people in research can improve enrolment, ... -
The Irish health system and the crisis: a case study in the struggle for the capacity of the Social State
(2018)Ireland’s health care system is a weak Beveridgean system with no entitlement to free care and substantial acute waiting lists. Just under half the population has voluntary private health insurance and there is a two-tier ... -
Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice.
(2019)Among the changes that typify Alzheimer’s disease (AD) are neuroinflammation and microglial activation, amyloid deposition perhaps resulting from compromised microglial function and iron accumulation. Data from Genome Wide ... -
The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG
(2021)For over 50 years, patients with drug-sensitive and drug-resistant tuberculosis have undergone long, arduous, and complex treatment processes with several antimicrobials. With the prevalence of drug-resistant strains on ... -
Is "clinical" insight the same as "cognitive" insight in schizophrenia?
(2009)Poor insight is associated with impaired cognitive function in psychosis. Whether poor clinical insight overlaps with other aspects of self-awareness in schizophrenia, such as cognitive self-awareness, is unclear. We ... -
Is 'Clinical' insight the same as 'Cognitive' insight in schizophrenia?
(Cambridge University Press, 2009)Poor insight is associated with impaired cognitive function in psychosis. Whether poor clinical insight overlaps with other aspects of self-awareness in schizophrenia, such as cognitive self-awareness, is unclear. We ... -
Is it time to reconsider the treatment paradigm for obese patients with hypertension?
(2022)The recent STEP trials reported blood pressure reductions for obese patients treated with semaglutide. We analyzed a cohort of patients attending our hypertension clinic and found that 26% were severely or morbidly obese ... -
Is low iron status a risk factor for neural tube defects?
(2014)Background: Folic acid supplements can protect against neural tube defects (NTDs). Low folate and low vitamin B12 status may be maternal risk factors for having an NTD affected pregnancy. However, not all NTDs are preventable ... -
Is orthostatic hypotension more common in individuals with atrial fibrillation? – Findings from The Irish Longitudinal Study on Ageing (TILDA)
(2017)Introduction: atrial fibrillation (AF) and orthostatic hypotension (OH) share common risk factors such as age, hypertension and cardiovascular (CV) disease. The autonomic nervous system (ANS) also plays a role in the ... -
Is phenotypical prefrailty all the same? A longitudinal investigation of two prefrailty subtypes in TILDA
(2019)Background: Fried's frailty phenotype is defined by five criteria: exhaustion, unexplained weight loss, weakness, slowness and low physical activity. Prefrailty (PF) meets one or two criteria. PF is of interest as a target ... -
Is the FTP Test a Reliable, Reproducible and Functional Assessment Tool in Highly-Trained Athletes?
(2019)The aim of the current study was to assess reliability of the Functional Threshold Power test (FTP) and the corresponding intensity sustainable for 1-hour in a "quasi-steady state". Highly-trained athletes (n = 19) completed ... -
Ischaemia-reperfusion-induced renal injury : pathogenesis & modulation implications for transplantation
(Trinity College (Dublin, Ireland). Department of Physiology, 2004)Ischaemia-reperfusion is unavoidable during transplantation, but may promote allograft rejection. Preconditioning with a sub-lethal stress protects cells against a subsequent otherwise lethal stress, possibly through the ... -
Ischaemic stroke or TIA in older subjects associated with impaired dynamic blood pressure control in the absence of severe large artery stenosis.
(2015)Background: older subjects may require higher baseline blood pressures to maintain cerebral perfusion. We investigated whether episodic hypotension is associated with tissue infarction in subjects with syncopal symptoms ...