Browsing School of Medicine by Title
Now showing items 1-20 of 3152
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1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours
(2019)Colorectal cancer (CRC) is the second leading cause of cancer associated deaths in developed countries. Cancer progression and metastatic spread is reliant on new blood vasculature, or angiogenesis. Tumour-related angiogenesis ... -
12 weeks of simulated barefoot running changes foot-strike patterns in female runners
(2014)To investigate the effect of a transition program of simulated barefoot running (SBR) on running kinematics and foot-strike patterns, female recreational athletes (n=9, age 29 ± 3 yrs) without SBR experience gradually ... -
A 2.5min cold water immersion improves prolonged intermittent sprint performance
(2019)Objectives: We investigated if cold water immersion (CWI) affects exercise performance during a prolonged intermittent sprint test (IST), designed to mimic activity patterns of team-sports. Design: Randomized-crossover ... -
2012 - That was the year that was
(2013)Geriatric medicine has an encyclopaedic sweep, reflecting the complexity of both the ageing process and of our patient group. Keeping up with, and making sense of, the relevant scientific literature is challenging, especially ... -
2018 ESC Guidelines for the diagnosis and management of syncope
(2018)Guidelines summarize and evaluate available evidence with the aim of assisting health professionals in selecting the best management strategies for an individual patient with a given condition. Guidelines and their ... -
2020 international consensus on ANCA testing beyond systemic vasculitis
(2020)This document follows up on a 2017 revised international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic polyangiitis and focuses on the clinical and ... -
2021 consensus statement for preventing and managing low back pain in elite and subelite adult rowers
(2021)Purpose: To synthesise evidence on low back pain (LBP) in adult rowers and to create a consensus statement to inform clinical practice. Methods: There were four synthesis steps that informed the consensus statement. In ... -
23. Lessons of ALS imaging: Pitfalls and future directions - A critical review.
(2014)Stereotypical shortcomings can be identified in ALS neuroimaging studies. • A systematic discussion of ALS study limitations is particularly timely. • Individual patient data meta-analyses and multicentre ... -
24-hour ambulatory electrocardiographic monitoring is unhelpful in the investigation of older persons with recurrent falls
(2005)Background: although frequently used in the assessment of patients with falls, it is unclear whether 24-hour ambulatory electrocardiography contributes to their assessment in older persons. Objective: to ... -
2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up.
(2014)To complement the existing treatment guidelines for all tumour types, ESMO organises consensus conferences to focus on specific issues in each type of tumour. The 2nd ESMO Consensus Conference on Lung Cancer was held on ... -
A 39kDa fragment of endogenous ASK1 suggests specific cleavage not degradation by the proteasome.
(John Wiley, 2008)Transfected human ASK1 produces a 150kDa protein. However, we have detected endogenous ASK1 predominantly as 39kDa and 50kDa C-terminal and 75kDa and 110kDa N-terminal fragments in a panel of non-transfected cancer cell ... -
3D Bioprinting of Anatomically Accurate Implants for Meniscus Tissue Engineering
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2020)Menisci are soft tissues essential for load bearing and stress distribution in the knee joint. Meniscal injuries are common in all age groups and can lead to degeneration of the joint. While currently available surgical ... -
A 5-Year Audit of Paediatric Patients Presenting to an Emergency Department with Status Epilepsy Requiring Second-Line Medication
(2023)Aim: Audit management of children presenting to Paediatric Emergency Department (PED) who require second-line medication for seizure control. Method: Retrospective electronic chart review over a 5-year period (March ... -
α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
(2015)The immunoregulatory function of single-Ig-interleukin-1 related receptor (SIGIRR) is derived from its ability to constrain the inflammatory consequences of interleukin (IL)-1R and toll-like receptor (TLR)4 activation. ... -
A candidate gene search for autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2006)This research involved a candidate gene search for autism in the Irish population. It sought to identify candidate genes based on information from linkage studies, reports of chromosomal abnormalities, animal studies and ...