Browsing Psychiatry by Author "BOLSHAKOVA, NADIA"

Now showing items 1-3 of 3

    • Application of simulated annealing to the biclustering of gene expression data 

      BOLSHAKOVA, NADIA; CUNNINGHAM, PADRAIG (2006)
      In a gene expression data matrix, a bicluster is a submatrix of genes and conditions that exhibits a high correlation of expression activity across both rows and columns. The problem of locating the most significant ...

    • Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders 

      MERIKANGAS, ALISON; GALLAGHER, LOUISE; BOLSHAKOVA, NADIA (2014)
      Rare copy-number variation (CNV) is an important source of risk for autism spectrum disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic deletions and duplications in affected versus ...

    • A genomewide scan for common alleles affecting risk for autism. 

      ANNEY, RICHARD; GALLAGHER, LOUISE; GILL, MICHAEL; BOLSHAKOVA, NADIA; SEGURADO, RICARDO; HERON, ELIZABETH; MCGRATH, JANE; TANSEY, KATHERINE; BRENNAN, SEAN; MERIKANGAS, ALISON; MERIKANGAS, ALISON KATHLEEN (2010)
      Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the ...