Browsing Psychiatry by Author "BOKDE, ARUN LAWRENCE WARREN"
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Assessing neuronal networks: Understanding Alzheimer's disease
HAMPEL, HARALD; BOKDE, ARUN LAWRENCE WARREN (2009)Findings derived from neuroimaging of the structural and functional organization of the human brain have led to the widely supported hypothesis that neuronal networks of temporally coordinated brain activity across different ... -
Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease
HAMPEL, HARALD; BOKDE, ARUN LAWRENCE WARREN (2010)Subjects with mild cognitive impairment (MCI) have an increased risk to develop Alzheimer?s disease (AD). Voxel-based MRI studies have demonstrated that widely distributed cortical and subcortical brain areas show atrophic ... -
Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease.
BOKDE, ARUN LAWRENCE WARREN; HAMPEL, HARALD (Elsevier, 2011)During the last two decades, imaging of neural activation has become an invaluable tool for assessing the functional organization of the human brain in vivo. Due to its widespread application in neuroscience, functional ... -
Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer s Disease
COUGHLAN, TARA LEAH; BOKDE, ARUN LAWRENCE WARREN; COLLINS, DANIEL RONAN; O'NEILL, DESMOND; HAMPEL, HARALD; TANNER, COLBY; BARTLEY, MAIREAD MARY (PLoS, 2011)The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, ... -
The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals
FRODL, THOMAS; DONOHOE, GARY (JAMES); GILL, MICHAEL; CORVIN, AIDEN PETER; NEWELL, FIONA; ROSE, EMMA; FAHEY, CIARA; GARAVAN, HUGH PATRICK; BOKDE, ARUN LAWRENCE WARREN; O'DOHERTY, JOHN PHILIP; MC GRATH, JANE; KELLY, SINEAD; ROBERTSON, IAN H; MORRIS, DEREK (Elsevier, 2012)A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we investigated ... -
On the development of markers for pathological TDP-43 in amyotrophic lateral sclerosis with and without dementia
BOKDE, ARUN LAWRENCE WARREN; BEDE, PETER; HAMPEL, HARALD; HARDIMAN, ORLA (Elsevier, 2011)Pathological 43-kDa transactive responsive sequence DNA-binding protein (TDP-43) has been recognized as the major disease protein in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin ... -
White matter microstructure underlying default mode network connectivity in the human brain
HAMPEL, HARALD; BOKDE, ARUN LAWRENCE WARREN (2010)Resting state functional magnetic resonance imaging (fMRI) reveals a distinct network of correlated brain function representing a default mode state of the human brain. The underlying structural basis of this functional ...