Browsing Psychiatry by Date of Publication
Now showing items 21-40 of 434
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Developmental comorbidity assessment in childhood ADHD
(2003)Introduction: Childhood ADHD typically presents with comorbidites. Assessment tools for developmental screening vary greatly in length and complexitity, and parental preference has an impact on the usefulness of clinical ... -
Compliance Therapy: A Randomised Controlled Trial In Schizophrenia.
(2003)OBJECTIVE: To evaluate the efficacy of "compliance therapy" for improving adherence to prescribed drug treatment among patients with schizophrenia. DESIGN: Randomised controlled trial. SETTING: Urban catchment ... -
The influence of Alzheimer's dementia on time spent caregiving for persons with Down Syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2003)Background: Persons with Down syndrome (DS) are at increased risk of Alzheimer’s type dementia (AD) when compared to the general population, yet little attention has been paid to the impact of the illness on such persons ... -
Electroconvulsive therapy - state of the art
(The Royal College of Physicians, 2003)Although electroconvulsive therapy (ECT) has been available for more than 60 years it is still the most acutely effective antidepressant treatment available (McCall, 2001). However, despite substantial advances in safety ... -
Caring for a child with an autistic spectrum disorder over the life span
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2003)Carers of children on the autistic spectrum have stressful lives (Randall & Parker, 1999). The aim of this study was to investigate the life of the carer, and in particular to examine how they have coped, their support ... -
Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
(2003)Genome scans of bipolar disorder (BPD) have not produced consistent evidence for linkage. The rank-based genome scan meta-analysis (GSMA) method was applied to 18 BPD genome scan data sets in an effort to identify regions ... -
Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.
(The Society for Neuroscience, 2003)Here we characterize a novel neuronal kinase, cyclin-dependent kinase 5 (cdk5)/p35-regulated kinase (cprk). Cprk is a member of a previously undescribed family of kinases that are predicted to contain two N-terminal ... -
Psychiatric Genetics in the post genome age
(The Royal College of Psychiatrists, 2003)Less than 50 years after publication of the structure of DNA, we possess a working draft of the human genome and expect a completed draft listing all genes and their location by 2003 (International Human Genome Sequencing ... -
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
(American Society for Biochemistry and Molecular Biology, 2004)The amyloid precursor protein (APP) is proteolytically processed to release a C-terminal domain that signals to the nucleus to regulate transcription of responsive genes. The APP C terminus binds to a number of phosphotyrosine ... -
Joint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypes
(2004)Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable, heterogeneous disorder of early onset, consisting of a triad of symptoms: inattention, hyperactivity, and impulsivity. The disorder has a significant ... -
The Depression Network (DeNT) Study: Methodology and Sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetics study
(BMC, 2004)Background: The Depression Network Study (DeNt) is a multicentre study designed to identify genes and/or loci linked to and/or associated with susceptibility to unipolar depression in Caucasian families. This study ... -
Molecular genetics investigations in autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2004)This research thesis involved the establishment and management of a research group in autism genetics in addition to the collection of an autism sample of parent-child trios. A well-characterised sample of individuals with ... -
Mental Illness in Irish Prisoners
(National Forensic Mental Health Service, Dundrum, Dublin 14, Ireland, 2004-12)This is the first systematic and representative survey of psychiatric morbidity in the Irish Prison population, using standardised research diagnostic methods. Five samples have been compiled, including 7% of all men ... -
Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31
(American Psychiatric Association, 2005)OBJECTIVE: Autism is a neurodevelopmental disorder with childhood onset and a known major genetic component. A recent study identified a highly significant association between autism and a two-single-nucleotide-polymorphism ... -
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
(American Society for Biochemistry and Molecular Biology, 2005)Rac and its downstream effectors p21-activated kinase (PAK) family kinases regulate actin dynamics within growth cones to control neurite outgrowth during development. The activity of Rac is stimulated by guanine ... -
Methodological issues in event-related fMRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2005)Functional magnetic resonance imaging (fMRI) is a very powerful tool for localising psychological functions to specific brain areas. Recently, there has been a surge of interest in determining the functional differences ... -
Genetic mouse models of Alzheimer's disease.
(Freund and Pettman, 2005)In the current minireview, we focus on genetic mouse models of Alzheimer's disease (AD). Because various excellent, up-to-date reviews, special issues, and reliable websites are already dedicated to the genetics of Alzheimer's ...